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Proliferation, cell cycle and apoptosis in cancer

Author

Listed:
  • Gerard I. Evan

    (UCSF Cancer Center)

  • Karen H. Vousden

    (NCI at Frederick)

Abstract

Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.

Suggested Citation

  • Gerard I. Evan & Karen H. Vousden, 2001. "Proliferation, cell cycle and apoptosis in cancer," Nature, Nature, vol. 411(6835), pages 342-348, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077213
    DOI: 10.1038/35077213
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    2. W. Frank Lenoir & Micaela Morgado & Peter C. DeWeirdt & Megan McLaughlin & Audrey L. Griffith & Annabel K. Sangree & Marissa N. Feeley & Nazanin Esmaeili Anvar & Eiru Kim & Lori L. Bertolet & Medina C, 2021. "Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Jae-Woong Min & Woo Jin Kim & Jeong A Han & Yu-Jin Jung & Kyu-Tae Kim & Woong-Yang Park & Hae-Ock Lee & Sun Shim Choi, 2015. "Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    4. Song Zhang & Qianyi Xiao & Zhuqing Shi & Guopeng Yu & Xiao-Pin Ma & Haitao Chen & Pengyin Zhang & Suqin Shen & He-Xi Ge Sai-Yin & Tao-Yang Chen & Pei-Xin Lu & Neng-Jin Wang & Weihua Ren & Peng Huang &, 2017. "Caspase polymorphisms and prognosis of hepatocellular carcinoma," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    5. Neha Pal & Shalini Rathore & Priya Kaushik & Swati Tyagi & Abhimanyu Kumar Jha & Anshuman Kumar, 2019. "Promoter Hypermethylation of Apoptotic genes in Oral Squamous Cell Carcinoma," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 13(5), pages 103-108, May.
    6. Menchón, S.A. & Condat, C.A., 2011. "Quiescent cells: A natural way to resist chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 390(20), pages 3354-3361.
    7. Zhou Zhong-Xing & Mi Yuan-Yuan & Ma Hai Zhen & Zou Jian-Gang & Zhang Li-Feng, 2013. "FAS-1377 G/A (rs2234767) Polymorphism and Cancer Susceptibility: A Meta-Analysis of 17,858 Cases and 24,311 Controls," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    8. Anthony Szedlak & Spencer Sims & Nicholas Smith & Giovanni Paternostro & Carlo Piermarocchi, 2017. "Cell cycle time series gene expression data encoded as cyclic attractors in Hopfield systems," PLOS Computational Biology, Public Library of Science, vol. 13(11), pages 1-19, November.
    9. Yi Fu & Robert Kunz & Jianhua Wu & Cheng Dong, 2012. "Study of Local Hydrodynamic Environment in Cell-Substrate Adhesion Using Side-View μPIV Technology," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-13, February.
    10. Yongzhi Yang & Feng Wang & Chenzhang Shi & Yang Zou & Huanlong Qin & Yanlei Ma, 2012. "Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-9, May.
    11. Lei Xu & Xin Zhou & Feng Jiang & Man-Tang Qiu & Zhi Zhang & Rong Yin & Lin Xu, 2013. "FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-9, September.
    12. David A Knowles & Gina Bouchard & Sylvia Plevritis, 2019. "Sparse discriminative latent characteristics for predicting cancer drug sensitivity from genomic features," PLOS Computational Biology, Public Library of Science, vol. 15(5), pages 1-18, May.

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