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MazEF homologous Modules System and A Post-segregational killing Mechanism (Bacteriostatic & Bactericidal Mechanism) of Novel Compound Isolated from Spondias monbinon Escherichia Coli and Bacillus Subtilis

Author

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  • Oludare Temitope Osuntokun

    (Department of Microbiology, Adekunle Ajasin University, Nigeria)

  • Olaposi A Omotuyi

    (Centre for Biocomputing and Drug Development (CBDD), Adekunle Ajasin University, Nigeria)

  • Anthonia O Oluduro

    (ubmission: February 14, 2019; Published: March 08, 2019)

Abstract

The basic objective of this research work is to evaluate the mechanism of action of compound Epigallocatechin, Epicatechin and Stigmasterol Phytosterol (Synergy), Aspidofractinine-3-methanol) and Terephthalic acid, dodecyl 2-ethylhexyl ester with Selected clinical isolates by using molecular biomarker MazEF9 TA system. Toxin-Antitoxin (TA) systems are highly conserved in members of the Gram positive +ve and Gram negative –ve bacteria which has been proposed to play an important role in physiology and virulence. Clinical microorganisms were cultured and Sub-culturing in Department of Microbiology and Centre for Biocomputing and Drug Development (CBDD), Adekunle Ajasin University, Akungba Akoko, Ondo-state, Nigeria. A 12 hours old culture of each microorganism was re-suspended in plant extract at 1000 μg mL in a total volume of 500μl for 0, 15, 30, 45, 60, and 180 minutes.

Suggested Citation

  • Oludare Temitope Osuntokun & Olaposi A Omotuyi & Anthonia O Oluduro, 2019. "MazEF homologous Modules System and A Post-segregational killing Mechanism (Bacteriostatic & Bactericidal Mechanism) of Novel Compound Isolated from Spondias monbinon Escherichia Coli and Bacillus Sub," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(5), pages 101-109, February.
    • Handle: RePEc:adp:ijcsmb:v:5:y:2019:i:5:p:101-109
    DOI: 10.19080/IJCSMB.2019.04.555673
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    1. Martin Raff, 1998. "Cell suicide for beginners," Nature, Nature, vol. 396(6707), pages 119-119, November.
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