IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0176566.html
   My bibliography  Save this article

Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2

Author

Listed:
  • Myoung Keun Lee
  • John R Shaffer
  • Elizabeth J Leslie
  • Ekaterina Orlova
  • Jenna C Carlson
  • Eleanor Feingold
  • Mary L Marazita
  • Seth M Weinberg

Abstract

Several studies have now shown evidence of association between common genetic variants and quantitative facial traits in humans. The reported associations generally involve simple univariate measures and likely represent only a small fraction of the genetic loci influencing facial morphology. In this study, we applied factor analysis to a set of 276 facial linear distances derived from 3D facial surface images of 2187 unrelated individuals of European ancestry. We retained 23 facial factors, which we then tested for genetic associations using a genome-wide panel of 10,677,593 single nucleotide polymorphisms (SNPs). In total, we identified genome-wide significant (p

Suggested Citation

  • Myoung Keun Lee & John R Shaffer & Elizabeth J Leslie & Ekaterina Orlova & Jenna C Carlson & Eleanor Feingold & Mary L Marazita & Seth M Weinberg, 2017. "Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0176566
    DOI: 10.1371/journal.pone.0176566
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176566
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0176566&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0176566?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. John Horn, 1965. "A rationale and test for the number of factors in factor analysis," Psychometrika, Springer;The Psychometric Society, vol. 30(2), pages 179-185, June.
    2. John R Shaffer & Ekaterina Orlova & Myoung Keun Lee & Elizabeth J Leslie & Zachary D Raffensperger & Carrie L Heike & Michael L Cunningham & Jacqueline T Hecht & Chung How Kau & Nichole L Nidey & Lina, 2016. "Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology," PLOS Genetics, Public Library of Science, vol. 12(8), pages 1-21, August.
    3. Bryan N Howie & Peter Donnelly & Jonathan Marchini, 2009. "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
    4. Tohru Kitada & Shuichi Asakawa & Nobutaka Hattori & Hiroto Matsumine & Yasuhiro Yamamura & Shinsei Minoshima & Masayuki Yokochi & Yoshikuni Mizuno & Nobuyoshi Shimizu, 1998. "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism," Nature, Nature, vol. 392(6676), pages 605-608, April.
    5. Mary E. Dickinson & Ann M. Flenniken & Xiao Ji & Lydia Teboul & Michael D. Wong & Jacqueline K. White & Terrence F. Meehan & Wolfgang J. Weninger & Henrik Westerberg & Hibret Adissu & Candice N. Baker, 2016. "High-throughput discovery of novel developmental phenotypes," Nature, Nature, vol. 537(7621), pages 508-514, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ziyi Xiong & Xingjian Gao & Yan Chen & Zhanying Feng & Siyu Pan & Haojie Lu & Andre G. Uitterlinden & Tamar Nijsten & Arfan Ikram & Fernando Rivadeneira & Mohsen Ghanbari & Yong Wang & Manfred Kayser , 2022. "Combining genome-wide association studies highlight novel loci involved in human facial variation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Maria Lidia Mascia & Mirian Agus & Łukasz Tomczyk & Natale Salvatore Bonfiglio & Diego Bellini & Maria Pietronilla Penna, 2023. "Smartphone Distraction: Italian Validation of the Smartphone Distraction Scale (SDS)," IJERPH, MDPI, vol. 20(15), pages 1-15, August.
    2. Patrick Hylton & Ben Kisby & Paul Goddard, 2018. "Young People’s Citizen Identities: A Q-Methodological Analysis of English Youth Perceptions of Citizenship in Britain," Societies, MDPI, vol. 8(4), pages 1-21, December.
    3. Asmundur Oddsson & Patrick Sulem & Gardar Sveinbjornsson & Gudny A. Arnadottir & Valgerdur Steinthorsdottir & Gisli H. Halldorsson & Bjarni A. Atlason & Gudjon R. Oskarsson & Hannes Helgason & Henriet, 2023. "Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Van Acker, Veronique & Ho, Loan & Stevens, Larissa & Mulley, Corinne, 2020. "Quantifying the effects of childhood and previous residential experiences on the use of public transport," Journal of Transport Geography, Elsevier, vol. 86(C).
    5. Orazio Attanasio & Sarah Cattan & Emla Fitzsimons & Costas Meghir & Marta Rubio-Codina, 2020. "Estimating the Production Function for Human Capital: Results from a Randomized Controlled Trial in Colombia," American Economic Review, American Economic Association, vol. 110(1), pages 48-85, January.
    6. Leiv Gabrielsen & Pål Ulleberg & Reidulf Watten, 2012. "The Adolescent Life Goal Profile Scale: Development of a New Scale for Measurements of Life Goals Among Young People," Journal of Happiness Studies, Springer, vol. 13(6), pages 1053-1072, December.
    7. Daniel Svensson & Matilda Rentoft & Anna M Dahlin & Emma Lundholm & Pall I Olason & Andreas Sjödin & Carin Nylander & Beatrice S Melin & Johan Trygg & Erik Johansson, 2020. "A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences," PLOS ONE, Public Library of Science, vol. 15(9), pages 1-18, September.
    8. Chuan Gao & Nan Wang & Xiuqing Guo & Julie T Ziegler & Kent D Taylor & Anny H Xiang & Yang Hai & Steven J Kridel & Jerry L Nadler & Fouad Kandeel & Leslie J Raffel & Yii-Der I Chen & Jill M Norris & J, 2015. "A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    9. Franke, Nikolaus & Shah, Sonali, 2003. "How communities support innovative activities: an exploration of assistance and sharing among end-users," Research Policy, Elsevier, vol. 32(1), pages 157-178, January.
    10. Elise Verot & Paul Bonjean & Robin Chaux & Julie Gagnaire & Amandine Gagneux-Brunon & Bruno Pozzetto & Philippe Berthelot & Elisabeth Botelho-Nevers & Franck Chauvin, 2022. "Development and Validation of the COVID-19 Knowledges and Behavior Questionnaire in a French Population (CoVQuest-CC)," IJERPH, MDPI, vol. 19(5), pages 1-22, February.
    11. Zaitun Mohd Saman & Ab Hamid Siti-Azrin & Azizah Othman & Yee Cheng Kueh, 2021. "The Validity and Reliability of the Malay Version of the Cyberbullying Scale among Secondary School Adolescents in Malaysia," IJERPH, MDPI, vol. 18(21), pages 1-12, November.
    12. Marcin Gąsior, 2021. "Environmental Attitudes and Willingness to Purchase Online—Classification Approach," Sustainability, MDPI, vol. 13(15), pages 1-17, August.
    13. Michele Villa & Colette Balice-Bourgois & Angela Tolotti & Anna Falcó-Pegueroles & Serena Barello & Elena Corina Luca & Luca Clivio & Annette Biegger & Dario Valcarenghi & Loris Bonetti, 2021. "Ethical Conflict and Its Psychological Correlates among Hospital Nurses in the Pandemic: A Cross-Sectional Study within Swiss COVID-19 and Non-COVID-19 Wards," IJERPH, MDPI, vol. 18(22), pages 1-14, November.
    14. Harbatkin, Erica & Strunk, Katharine O. & McIlwain, Aliyah, 2023. "School turnaround in a pandemic: An examination of the outsized implications of COVID-19 on low-performing turnaround schools, districts, and their communities," Economics of Education Review, Elsevier, vol. 97(C).
    15. Walter Renner & Maximilian Wertz, 2015. "Valence and Efficacy: The Affective Meanings of Human Values and their Relationship to Moral Decisions," International Journal of Business and Social Research, MIR Center for Socio-Economic Research, vol. 5(6), pages 44-55, June.
    16. Fernando Bucheli, 2021. "Before Entering Adulthood: Developing an Index of Capabilities for Young Adults in Bogota," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 16(3), pages 965-1002, June.
    17. Yoo, Sun-Young & Vonk, M. Elizabeth, 2012. "The development and initial validation of the Immigrant Parental Stress Inventory (IPSI) in a sample of Korean immigrant parents," Children and Youth Services Review, Elsevier, vol. 34(5), pages 989-998.
    18. Varsamo Antoniou & Konstantinos Pasias & Nektarios Loukidis & Kalliopi K. Exarchou-Kouveli & Demosthenes B. Panagiotakos & Sherry L. Grace & Garyfallia Pepera, 2023. "Translation, Cross-Cultural Adaptation and Psychometric Validation of the Greek Version of the Cardiac Rehabilitation Barriers Scale (CRBS-GR): What Are the Barriers in South-East Europe?," IJERPH, MDPI, vol. 20(5), pages 1-10, February.
    19. Alecia J Carter & William E Feeney, 2012. "Taking a Comparative Approach: Analysing Personality as a Multivariate Behavioural Response across Species," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.
    20. Bart Neuts & Peter Nijkamp & Eveline Van Leeuwen, 2012. "Crowding Externalities from Tourist Use of Urban Space," Tourism Economics, , vol. 18(3), pages 649-670, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0176566. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.