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High Serum Tumor Necrosis Factor-Alpha Levels in Women with Polycystic Ovary Syndrome: A Meta-Analysis

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  • Lingling Gao
  • Yang Gu
  • Xianghua Yin

Abstract

The objective of the study is to assess the TNF-α levels in PCOS patients and healthy controls. A comprehensive electronic search in Medline, Embase, and the Cochrane Library database was conducted up to July 2016. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty-nine studies with a total of 1960 participants (1046 PCOS patients and 914 controls) were included in this meta-analysis. The TNF-α levels in PCOS patients were significantly higher than those in controls (random-effects, SMD = 0.60, 95% CI = 0.28–0.92, P 1.72(SMD = 0.967, 95% CI = 0.103–1.831, P = 0.028, I2 = 93.5%) and T ratio>2.10 (SMD = 1.420, 95% CI = 0.429–2.411, P = 0.005, I2 = 96.1%). By meta-regression it was suggested that ethnicity might contribute little to the heterogeneity between the included studies. Through cumulative meta-analysis and sensitivity analysis it was supposed that the higher TNF-α levels of PCOS patients compared to healthy controls was stable and reliable. This meta-analysis suggests that the circulating TNF-α levels in women with PCOS are significantly higher than those in healthy controls. It may be involved in promoting insulin resistance and androgen excess of PCOS.

Suggested Citation

  • Lingling Gao & Yang Gu & Xianghua Yin, 2016. "High Serum Tumor Necrosis Factor-Alpha Levels in Women with Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-18, October.
  • Handle: RePEc:plo:pone00:0164021
    DOI: 10.1371/journal.pone.0164021
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    References listed on IDEAS

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    1. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
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    1. Tahereh Raeisi & Hossein Rezaie & Mina Darand & Akram Taheri & Nazila Garousi & Bahman Razi & Leonardo Roever & Reza Mohseni & Shimels Hussien Mohammed & Shahab Alizadeh, 2021. "Circulating resistin and follistatin levels in obese and non-obese women with polycystic ovary syndrome: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.

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