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Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis

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Listed:
  • Fucheng Cai
  • Xiyue Xiao
  • Xun Niu
  • Hao Shi
  • Yi Zhong

Abstract

Background: O6-methylguanine-DNA methyl-transferase (MGMT) gene, a DNA repair gene, plays a critical role in the repair of alkylated DNA adducts that form following exposure to genotoxic agents. MGMT is generally expressed in various tumors, and its function is frequently lost because of hypermethylation in the promoter. The promoter methylation of MGMT has been extensively investigated in head and neck squamous cell carcinoma (HNSCC). However, the association between the promoter methylation of MGMT and HNSCC risk remains inconclusive and inconsistent. Therefore, we performed a meta-analysis to better clarify the association between the promoter methylation of MGMT and HNSCC risk. Methods: A systematical search was conducted in PubMed, Web of Science, EMBASE, and Ovid for studies on the association between MGMT promoter methylation and HNSCC. Odds ratio (ORs) and 95% confidence intervals (CI) were calculated to estimate association between MGMT promoter methylation and risk of HNSCC. The meta-regression and subgroup analysis were undertaken to explore the potential sources of heterogeneity. Results: Twenty studies with 1,030 cases and 775 controls were finally included in this study. The frequency of MGMT promoter methylation was 46.70% in HNSCC group and 23.23% in the control group. The frequency of MGMT promoter methylation in HNSCC group was significantly higher than the control group (OR = 2.83, 95%CI = 2.25–3.56). Conclusion: This meta-analysis indicates that aberrant methylation of MGMT promoter was significantly associated with the risk of HNSCC, and it may be a potential molecular marker for monitoring the disease and may provide new insights to the treatment of HNSCC.

Suggested Citation

  • Fucheng Cai & Xiyue Xiao & Xun Niu & Hao Shi & Yi Zhong, 2016. "Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0163534
    DOI: 10.1371/journal.pone.0163534
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    1. Hao Shi & Ya Li & Xiaozhong Wang & Cheng Lu & Lilan Yang & Changmei Gu & Jiaqiang Xiong & Yangxin Huang & Shixuan Wang & Meixia Lu, 2013. "Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-7, October.
    2. Hao Shi & Xiong Chen & Cheng Lu & Changmei Gu & Hongwei Jiang & RuiWei Meng & Xun Niu & Yangxin Huang & Meixia Lu, 2015. "Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.
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    1. Jin Huang & Jia-You Luo & Hong-Zhuan Tan, 2019. "Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-23, October.

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