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The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics

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  • Chihao Shao
  • Wenzhu Dai
  • Haili Li
  • Wenru Tang
  • Shuting Jia
  • Xiaoming Wu
  • Ying Luo

Abstract

Background: The function of the tumor suppressor gene RASSF1A in cancer cells has been detailed in many studies. However, due to the methylation of its promoter, the expression of RASSF1A is missing in most cancers. In the literature, we found that the conclusion regarding the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma was not unified. This study adopts the use of a meta-analysis and bioinformatics to explore the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma. Methods: Data on melanoma susceptibility were downloaded from the PubMed, Cochrane Library, Web of Science and Google Scholar databases, which were analyzed via a meta-analysis. The effect sizes were estimated by measuring an odds ratio (OR) with a 95% confidence interval (CI). We also used a chi-squared-based Q test to examine the between-study heterogeneity, and used funnel plots to evaluate publication bias. The data on melanoma prognosis, which were analyzed by bioinformatics methods, were downloaded from The Cancer Genome Atlas (TCGA) project. The effect sizes were estimated by measuring the hazard ratios (HRs) with a 95% confidence interval (CI). Results: Our meta-analysis included 10 articles. We found that RASSF1A gene promoter methylation was closely related to melanoma susceptibility (OR = 12.67, 95% CI: 6.16 ∼ 26.05, z = 6.90, P

Suggested Citation

  • Chihao Shao & Wenzhu Dai & Haili Li & Wenru Tang & Shuting Jia & Xiaoming Wu & Ying Luo, 2017. "The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0171676
    DOI: 10.1371/journal.pone.0171676
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    References listed on IDEAS

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    1. Changmei Gu & Jiachun Lu & Tianpen Cui & Cheng Lu & Hao Shi & Wenmao Xu & Xueli Yuan & Xiaobo Yang & Yangxin Huang & Meixia Lu, 2013. "Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    2. Jundong Gu & Yanjun Wen & Siwei Zhu & Feng Hua & Hui Zhao & Hongrui Xu & Jiacong You & Linlin Sun & Weiqiang Wang & Jun Chen & Qinghua Zhou, 2013. "Association between P16INK4a Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    3. Hao Shi & Ya Li & Xiaozhong Wang & Cheng Lu & Lilan Yang & Changmei Gu & Jiaqiang Xiong & Yangxin Huang & Shixuan Wang & Meixia Lu, 2013. "Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-7, October.
    4. Yong Jiang & Lin Cui & Wen-de Chen & Shi-hai Shen & Li-dong Ding, 2012. "The Prognostic Role of RASSF1A Promoter Methylation in Breast Cancer: A Meta-Analysis of Published Data," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-7, May.
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