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Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

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  • Hao Shi
  • Xiong Chen
  • Cheng Lu
  • Changmei Gu
  • Hongwei Jiang
  • RuiWei Meng
  • Xun Niu
  • Yangxin Huang
  • Meixia Lu

Abstract

Background: The p16INK4a is an important tumor suppressor gene (TSG) and aberrant methylation of promoter is known to be a major inactivation mechanism of the tumor suppressor and tumor-related genes. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of head and neck squamous cell carcinoma (HNSCC). However, some studies have reported differences in the methylation frequencies of P16INK4a promoter between cancer and the corresponding control group. Therefore, we conducted a meta-analysis to better identify the association. Methods: PubMed, Ovid, ISI Web of Science, and EMBASE were searched to identify eligible studies to evaluate the association of p16INK4a promoter methylation and HNSCC. Odds ratio (ORs) and 95% confidence intervals (95%CI) were calculated to evaluate the strength of association between p16INK4a promoter methylation and HNSCC. Results: A total of twenty-one studies with 1155 cases and 1017 controls were included in the meta-analysis. The frequencies of p16INK4a promoter methylation in the cancer group were significantly higher than those in the control group (cancer group: median: 46.67%, range = 7.84%-95.12%; control group: median: 18.37%, range = 0–83.33%; respectively). The pooled odds ratio was 3.37 (95%CI = 2.32–4.90) in the cancer group versus the corresponding control group under the random-effects model. Conclusion: This meta-analysis of 21 published studies identified that aberrant methylation of p16INK4a promoter was found to be significantly associated with HNSCC.

Suggested Citation

  • Hao Shi & Xiong Chen & Cheng Lu & Changmei Gu & Hongwei Jiang & RuiWei Meng & Xun Niu & Yangxin Huang & Meixia Lu, 2015. "Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0122302
    DOI: 10.1371/journal.pone.0122302
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    Cited by:

    1. Xiyue Xiao & Fucheng Cai & Xun Niu & Hao Shi & Yi Zhong, 2016. "Association between P16INK4a Promoter Methylation and Ovarian Cancer: A Meta-Analysis of 12 Published Studies," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.
    2. Fucheng Cai & Xiyue Xiao & Xun Niu & Hao Shi & Yi Zhong, 2016. "Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.

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