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Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis

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  • Jin Huang
  • Jia-You Luo
  • Hong-Zhuan Tan

Abstract

Background: In this research, an meta-analysis was performed for assessment of the associations between O6-methyguanine-DNA methyltransferase (MGMT) promoter hypermethylation possessing low-grade intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL), cervical cancer (CC), and clinicopathological characters of CC. Methods: Literature selection were conducted through searching PubMed, Web of science, EMBASE, China National Knowledge Infrastructure and Wanfang databases (up to November 2018). An assessment of associations between MGMT methylation and LSIL, HSIL, CC risk and clinicopathological characteristics was performed through pooled odds ratios (ORs) with relevant 95% confidence intervals (CIs). Subgroup analyses, meta-regressions and Galbraith plots were conducted to conduct an exploration on the possible sources of heterogeneity. The genome-wide DNA methylation array studies were extracted from Gene Expression Omnibus (GEO) databases for validation of these outcomes. Results: In this meta-analysis of 25 published articles, MGMT hypermethylation gradually elevated the rates among control group (12.16%), LSIL (20.92%), HSIL (36.33%) and CC (41.50%) specimens. MGMT promoter methylation was significant associated with the increased risk of LSIL by 1.74-fold (P

Suggested Citation

  • Jin Huang & Jia-You Luo & Hong-Zhuan Tan, 2019. "Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-23, October.
    • Handle: RePEc:plo:pone00:0222772
    DOI: 10.1371/journal.pone.0222772
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    References listed on IDEAS

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    1. Yong Ding & Qihua Yang & Bojun Wang & Guoliang Ye & Xiaoqiong Tong, 2016. "The Correlation of MGMT Promoter Methylation and Clinicopathological Features in Gastric Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-14, November.
    2. Fucheng Cai & Xiyue Xiao & Xun Niu & Hao Shi & Yi Zhong, 2016. "Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.
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