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Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis

Author

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  • Hao Shi
  • Ya Li
  • Xiaozhong Wang
  • Cheng Lu
  • Lilan Yang
  • Changmei Gu
  • Jiaqiang Xiong
  • Yangxin Huang
  • Shixuan Wang
  • Meixia Lu

Abstract

Background: The RAS association domain family protein 1a gene (RASSF1A) is one of the tumor suppressor genes (TSG). Inactivation of RASSF1A is critical to the pathogenesis of cancer. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of ovarian cancer. A number of studies have discussed association between RASSF1A promoter methylation and ovarian cancer. However, they were mostly based on a small number of samples and showed inconsist results, Therefore, we conducted a meta-analysis to better identify the association. Methods: Eligible studies were identified by searching the PubMed, EMBASE, Web of Science, and CNKI databases using a systematic searching strategy. We pooled the odds ratio (ORs) from individual studies using a fixed-effects model. We performed heterogeneity and publication bias analysis simultaneously. Results: Thirteen studies, with 763 ovarian cancer patients and 438 controls were included in the meta-analysis. The frequencies of RASSF1A promoter methylation ranged from 30% to 58% (median is 48%) in the cancer group and 0 to 21% (median is 0) in the control group. The frequencies of RASSF1A promoter methylation in the cancer group were significantly higher than those in the control group. The pooled odds ratio was 11.17 (95% CI = 7.51–16.61) in the cancer group versus the corresponding control group under the fixed-effects model. Conclusion: The results suggested that RASSF1A promoter methylation had a strong association with ovarian cancer.

Suggested Citation

  • Hao Shi & Ya Li & Xiaozhong Wang & Cheng Lu & Lilan Yang & Changmei Gu & Jiaqiang Xiong & Yangxin Huang & Shixuan Wang & Meixia Lu, 2013. "Association between RASSF1A Promoter Methylation and Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0076787
    DOI: 10.1371/journal.pone.0076787
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    Cited by:

    1. Chihao Shao & Wenzhu Dai & Haili Li & Wenru Tang & Shuting Jia & Xiaoming Wu & Ying Luo, 2017. "The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    2. Fucheng Cai & Xiyue Xiao & Xun Niu & Hao Shi & Yi Zhong, 2016. "Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.

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