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Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis

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  • Jingguang Li
  • Yajun Zhao
  • Rena Li
  • Lucas S Broster
  • Chenglin Zhou
  • Suyong Yang

Abstract

A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen’s d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen’s d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.

Suggested Citation

  • Jingguang Li & Yajun Zhao & Rena Li & Lucas S Broster & Chenglin Zhou & Suyong Yang, 2015. "Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0131820
    DOI: 10.1371/journal.pone.0131820
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    References listed on IDEAS

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    2. Gurdeep S Sagoo & Julian Little & Julian P T Higgins, 2009. "Systematic Reviews of Genetic Association Studies," PLOS Medicine, Public Library of Science, vol. 6(3), pages 1-7, March.
    3. Michael Kosfeld & Markus Heinrichs & Paul J. Zak & Urs Fischbacher & Ernst Fehr, 2005. "Oxytocin increases trust in humans," Nature, Nature, vol. 435(7042), pages 673-676, June.
    4. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Andrea Bonassi & Ilaria Cataldo & Giulio Gabrieli & Jia N. Foo & Bruno Lepri & Gianluca Esposito, 2020. "Oxytocin Receptor Gene Polymorphisms and Early Parental Bonding Interact in Shaping Instagram Social Behavior," IJERPH, MDPI, vol. 17(19), pages 1-20, October.

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