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Age-Dependent Sex Difference of the Incidence and Mortality of Status Epilepticus: A Twelve Year Nationwide Population-Based Cohort Study in Taiwan

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  • Cheung-Ter Ong
  • Shew-Meei Sheu
  • Ching-Fang Tsai
  • Yi-Sin Wong
  • Solomon Chih-Cheng Chen

Abstract

Status epilepticus (SE) is a serious neurologic emergency associated with a significant mortality. The objective of this study is to investigate its epidemiology in terms of age- and sex-specific incidences and mortality. By using the Taiwan National Health Insurance Research Database during 2000 to 2011, we identified hospitalized patients with a discharged diagnosis of SE and calculated the incidence and in-hospital mortality of SE with respect to age and sex. The overall incidence of SE was 4.61 per 100,000 person-years, which displayed a “J-shaped” distribution by age with a little higher under the age of 5 and highest over 60 years. The male-to-female rate ratio was 1.57 and it demonstrated a “mountain-shape” across ages with the peak at 45 to 49 years old. The in-hospital mortality was significantly lower in males (7.38%) than in females (11.12%) with an odds ratio of 0.64 (95% CI 0.56-0.72). Notably, the in-hospital mortality for females increased rapidly after the age of 40 to 45 years. The multivariate analysis found males had a significantly lower risk of mortality than females after, but not before, 45 years of age with an odds ratio of 0.56 (95% CI 0.49-0.65). Sex and age are crucial factors associated with the incidence and in-hospital mortality of SE. The females over 45 years of age have a higher risk of occurrence and mortality from SE. The underlying mechanism deserves further study.

Suggested Citation

  • Cheung-Ter Ong & Shew-Meei Sheu & Ching-Fang Tsai & Yi-Sin Wong & Solomon Chih-Cheng Chen, 2015. "Age-Dependent Sex Difference of the Incidence and Mortality of Status Epilepticus: A Twelve Year Nationwide Population-Based Cohort Study in Taiwan," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0122350
    DOI: 10.1371/journal.pone.0122350
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    1. Yu-Chun Chen & Hsiao-Yun Yeh & Jau-Ching Wu & Ingo Haschler & Tzeng-Ji Chen & Thomas Wetter, 2011. "Taiwan’s National Health Insurance Research Database: administrative health care database as study object in bibliometrics," Scientometrics, Springer;Akadémiai Kiadó, vol. 86(2), pages 365-380, February.
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