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Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms with Coronary Artery Disease: An Updated Meta-Analysis and Systematic Review

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  • Himanshu Rai
  • Farah Parveen
  • Sudeep Kumar
  • Aditya Kapoor
  • Nakul Sinha

Abstract

Several association studies of endothelial nitric oxide synthase (NOS3) gene polymorphisms with respect to coronary artery disease (CAD) have been published in the past two decades. However, their association with the disease, especially among different ethnic subgroups, still remains controversial. This prompted us to conduct a systematic review and an updated structured meta-analysis, which is the largest so far (89 articles, 132 separate studies, and a sample size of 69,235), examining association of three polymorphic forms of the NOS3 gene (i.e. Glu298Asp, T786-C and 27bp VNTR b/a) with CAD. In a subgroup analysis, we tested their association separately among published studies originating predominantly from European, Middle Eastern, Asian, Asian-Indian and African ancestries. The pooled analysis confirmed the association of all the three selected SNP with CAD in three different genetic models transcending all ancestries worldwide. The Glu298Asp polymorphism showed strongest association (OR range = 1.28–1.52, and P

Suggested Citation

  • Himanshu Rai & Farah Parveen & Sudeep Kumar & Aditya Kapoor & Nakul Sinha, 2014. "Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms with Coronary Artery Disease: An Updated Meta-Analysis and Systematic Review," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0113363
    DOI: 10.1371/journal.pone.0113363
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    1. Nikola Panic & Emanuele Leoncini & Giulio de Belvis & Walter Ricciardi & Stefania Boccia, 2013. "Evaluation of the Endorsement of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Statement on the Quality of Published Systematic Review and Meta-Analyses," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
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