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Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis

Author

Listed:
  • Pei-Hsuan Weng
  • Yi-Ling Huang
  • John H Page
  • Jen-Hau Chen
  • Jianfeng Xu
  • Stella Koutros
  • Sonja Berndt
  • Stephen Chanock
  • Meredith Yeager
  • John S Witte
  • Rosalind A Eeles
  • Douglas F Easton
  • David E Neal
  • Jenny Donovan
  • Freddie C Hamdy
  • Kenneth R Muir
  • Graham Giles
  • Gianluca Severi
  • Jeffrey R Smith
  • Carmela R Balistreri
  • Irene M Shui
  • Yen-Ching Chen

Abstract

Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews. Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls. Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity. Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.

Suggested Citation

  • Pei-Hsuan Weng & Yi-Ling Huang & John H Page & Jen-Hau Chen & Jianfeng Xu & Stella Koutros & Sonja Berndt & Stephen Chanock & Meredith Yeager & John S Witte & Rosalind A Eeles & Douglas F Easton & Dav, 2014. "Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0110569
    DOI: 10.1371/journal.pone.0110569
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    References listed on IDEAS

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    1. Longbiao Zhu & Hua Yuan & Tao Jiang & Ruixia Wang & Hongxia Ma & Shuangyue Zhang, 2013. "Association of TLR2 and TLR4 Polymorphisms with Risk of Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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