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Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Author

Listed:
  • Lidyane V Camelo
  • Luana Giatti
  • Jorge Alexandre Barbosa Neves
  • Paulo A Lotufo
  • Isabela M Benseñor
  • Dóra Chor
  • Rosane Härter Griep
  • Maria de Jesus Mendes da Fonseca
  • Pedro Guatimosim Vidigal
  • Ichiro Kawachi
  • Maria Inês Schmidt
  • Sandhi Maria Barreto

Abstract

Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association between life course SEP and C-reactive protein (CRP) levels in adulthood, and to evaluate the extent to which health-risk behaviors and metabolic alterations mediate this association. Additionally, we explored the possible modifying influence of gender. Methods and Findings: Our analytical sample comprised 13,371 participants from ELSA-Brasil baseline, a multicenter prospective cohort study of civil servants. SEP during childhood, young adulthood, and adulthood were considered. The potential mediators between life course SEP and CRP included clusters of health-risk behaviors (smoking, low leisure time physical activity, excessive alcohol consumption), and metabolic alterations (obesity, hypertension, low HDL, hypertriglyceridemia, and diabetes). Linear regression models were performed and structural equation modeling was used to evaluate mediation. Although lower childhood SEP was associated with higher levels of CRP in adult life, this association was not independent of adulthood SEP. However, CRP increased linearly with increasing number of unfavorable social circumstances during the life course (p trend

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  • Lidyane V Camelo & Luana Giatti & Jorge Alexandre Barbosa Neves & Paulo A Lotufo & Isabela M Benseñor & Dóra Chor & Rosane Härter Griep & Maria de Jesus Mendes da Fonseca & Pedro Guatimosim Vidigal & , 2014. "Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0108426
    DOI: 10.1371/journal.pone.0108426
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    References listed on IDEAS

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    1. G. David Batty & Abita Bhaskar & Carol Emslie & Michaela Benzeval & Geoff Der & Heather Lewars & Kate Hunt, 2012. "Association of life course socioeconomic disadvantage with future problem drinking and heavy drinking: gender differentials in the west of Scotland," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 57(1), pages 119-126, February.
    2. G. Batty & Abita Bhaskar & Carol Emslie & Michaela Benzeval & Geoff Der & Heather Lewars & Kate Hunt, 2012. "Erratum to: Association of life course socioeconomic disadvantage with future problem drinking and heavy drinking: gender differentials in the west of Scotland," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 57(1), pages 247-247, February.
    3. Loucks, Eric B. & Pilote, Louise & Lynch, John W. & Richard, Hugues & Almeida, Nisha D. & Benjamin, Emelia J. & Murabito, Joanne M., 2010. "Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study," Social Science & Medicine, Elsevier, vol. 71(1), pages 187-195, July.
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    5. Silvia Stringhini & G David Batty & Pascal Bovet & Martin J Shipley & Michael G Marmot & Meena Kumari & Adam G Tabak & Mika Kivimäki, 2013. "Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study," PLOS Medicine, Public Library of Science, vol. 10(7), pages 1-15, July.
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    1. Carmeli, Cristian & Steen, Johan & Petrovic, Dusan & Lepage, Benoît & Delpierre, Cyrille & Kelly-Irving, Michelle & Bochud, Murielle & Kivimäki, Mika & Vineis, Paolo & Stringhini, Silvia, 2020. "Mechanisms of life-course socioeconomic inequalities in adult systemic inflammation: Findings from two cohort studies," Social Science & Medicine, Elsevier, vol. 245(C).
    2. Camelo, Lidyane V. & Giatti, Luana & Chor, Dóra & Griep, Rosane Härter & Benseñor, Isabela M. & Santos, Itamar S. & Kawachi, Ichiro & Barreto, Sandhi Maria, 2015. "Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)," Social Science & Medicine, Elsevier, vol. 141(C), pages 91-99.

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