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Relative contribution of health-related behaviours and chronic diseases to the socioeconomic patterning of low-grade inflammation

Author

Listed:
  • Marialaura Bonaccio

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Augusto Di Castelnuovo

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • George Pounis

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Amalia De Curtis

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Simona Costanzo

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Mariarosaria Persichillo

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Chiara Cerletti

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Maria Benedetta Donati

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Giovanni de Gaetano

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

  • Licia Iacoviello

    (IRCCS Istituto Neurologico Mediterraneo NEUROMED)

Abstract

Objectives To test the association of low-grade inflammation with socioeconomic status (SES) and determine the relative contribution of prevalent chronic diseases and health-related behaviours in explaining such association. Methods Cross-sectional analysis on 19,867 subjects (age ≥35, 48.1% men) recruited within the Moli-sani study from 2005 to 2010 (Italy). A score of low-grade inflammation, including platelet and leukocyte counts, the granulocyte-to-lymphocyte ratio, and C-reactive protein was applied. SES was measured by education, household income, and occupational social class. Results Low SES was associated with elevated levels of low-grade inflammation. Health behaviours (including adiposity, smoking, physical activity, and Mediterranean diet adherence) explained 53.5, 53.9, and 84.9% of the association between social class, income, and education with low-grade inflammation, respectively. Adiposity and body mass index showed a prominent role, while prevalent chronic diseases and conditions only marginally attenuated SES inequalities in inflammation. Conclusions Low-grade inflammation was socioeconomically patterned in a large Mediterranean population. Potentially modifiable behavioural factors explained the greatest part of this association with a leading contribution of adiposity, body mass index, and physical activity.

Suggested Citation

  • Marialaura Bonaccio & Augusto Di Castelnuovo & George Pounis & Amalia De Curtis & Simona Costanzo & Mariarosaria Persichillo & Chiara Cerletti & Maria Benedetta Donati & Giovanni de Gaetano & Licia Ia, 2017. "Relative contribution of health-related behaviours and chronic diseases to the socioeconomic patterning of low-grade inflammation," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(5), pages 551-562, June.
    • Handle: RePEc:spr:ijphth:v:62:y:2017:i:5:d:10.1007_s00038-016-0939-0
    DOI: 10.1007/s00038-016-0939-0
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    References listed on IDEAS

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    1. Silvia Stringhini & G David Batty & Pascal Bovet & Martin J Shipley & Michael G Marmot & Meena Kumari & Adam G Tabak & Mika Kivimäki, 2013. "Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study," PLOS Medicine, Public Library of Science, vol. 10(7), pages 1-15, July.
    2. Khang, Young-Ho & Lynch, John W. & Yang, Seungmi & Harper, Sam & Yun, Sung-Cheol & Jung-Choi, Kyunghee & Kim, Hye Ryun, 2009. "The contribution of material, psychosocial, and behavioral factors in explaining educational and occupational mortality inequalities in a nationally representative sample of South Koreans: Relative an," Social Science & Medicine, Elsevier, vol. 68(5), pages 858-866, March.
    3. Marialaura Bonaccio & Augusto Di Castelnuovo & Simona Costanzo & Mariarosaria Persichillo & Maria Benedetta Donati & Giovanni de Gaetano & Licia Iacoviello, 2016. "Interaction between education and income on the risk of all-cause mortality: prospective results from the MOLI-SANI study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 61(7), pages 765-776, September.
    4. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
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