IDEAS home Printed from https://ideas.repec.org/a/eee/socmed/v71y2010i1p187-195.html
   My bibliography  Save this article

Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study

Author

Listed:
  • Loucks, Eric B.
  • Pilote, Louise
  • Lynch, John W.
  • Richard, Hugues
  • Almeida, Nisha D.
  • Benjamin, Emelia J.
  • Murabito, Joanne M.

Abstract

Associations between life course socioeconomic position (SEP) and novel biological risk markers for coronary heart disease such as inflammatory markers are not well understood. Most studies demonstrate inverse associations of life course SEP with C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen, however little is known about associations between life course SEP and other inflammatory markers including intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor II (TNFR2), lipoprotein phospholipase A2 (Lp-PLA2) activity, monocyte chemoattractant protein-1 (MCP-1) or P-selectin. The objectives of this analysis were to determine whether three life course SEP frameworks ("accumulation of risk", "social mobility" and "sensitive periods") are associated with the aforementioned inflammatory markers. We examined 1413 Framingham Offspring Study participants (mean age 61.2 ± 8.6 years, 54% women), using multivariable regression analyses. In age- and sex-adjusted regression analyses, cumulative SEP ("accumulation of risk" SEP framework), for low vs. high SEP, was inversely associated with CRP, IL-6, ICAM-1, TNFR2, Lp-PLA2 activity, MCP-1 and fibrinogen. We found that there were few consistent trends between social mobility trajectories and most inflammatory markers. Own educational attainment was inversely associated with 7 of 8 studied inflammatory markers, while father's education, father's occupation and own occupation were inversely associated with 4, 5 and 4 inflammatory markers, respectively, in age- and sex-adjusted analyses. The strengths of association between SEP and inflammatory markers were typically substantially accounted for by CHD risk markers (smoking, body mass index, systolic blood pressure, total:HDL cholesterol ratio, fasting glucose, medications, depressive symptomatology) suggesting these may be important mechanisms that explain associations between SEP and the studied inflammatory markers.

Suggested Citation

  • Loucks, Eric B. & Pilote, Louise & Lynch, John W. & Richard, Hugues & Almeida, Nisha D. & Benjamin, Emelia J. & Murabito, Joanne M., 2010. "Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study," Social Science & Medicine, Elsevier, vol. 71(1), pages 187-195, July.
    • Handle: RePEc:eee:socmed:v:71:y:2010:i:1:p:187-195
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0277-9536(10)00239-X
    Download Restriction: Full text for ScienceDirect subscribers only
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Hallqvist, Johan & Lynch, John & Bartley, Mel & Lang, Thierry & Blane, David, 2004. "Can we disentangle life course processes of accumulation, critical period and social mobility? An analysis of disadvantaged socio-economic positions and myocardial infarction in the Stockholm Heart Ep," Social Science & Medicine, Elsevier, vol. 58(8), pages 1555-1562, April.
    2. Lawlor, D.A. & Batty, G.D. & Morton, S.M.B. & Clark, H. & Macintyre, S. & Leon, D.A., 2005. "Childhood socioeconomic position, educational attainment, and adult cardiovascular Risk Factors: The Aberdeen children of the 1950s cohort study," American Journal of Public Health, American Public Health Association, vol. 95(7), pages 1245-1251.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Simons, Ronald L. & Lei, Man Kit & Beach, Steven R.H. & Philibert, Robert A. & Cutrona, Carolyn E. & Gibbons, Frederick X. & Barr, Ashley, 2016. "Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women," Social Science & Medicine, Elsevier, vol. 150(C), pages 192-200.
    2. Meghan B Azad & Yuri Lissitsyn & Gregory E Miller & Allan B Becker & Kent T HayGlass & Anita L Kozyrskyj, 2012. "Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    3. Alcántara, Carmela & Chen, Chih-Nan & Alegría, Margarita, 2014. "Do post-migration perceptions of social mobility matter for Latino immigrant health?," Social Science & Medicine, Elsevier, vol. 101(C), pages 94-106.
    4. Lidyane V Camelo & Luana Giatti & Jorge Alexandre Barbosa Neves & Paulo A Lotufo & Isabela M Benseñor & Dóra Chor & Rosane Härter Griep & Maria de Jesus Mendes da Fonseca & Pedro Guatimosim Vidigal & , 2014. "Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
    5. Hudson, Darrell L. & Puterman, Eli & Bibbins-Domingo, Kirsten & Matthews, Karen A. & Adler, Nancy E., 2013. "Race, life course socioeconomic position, racial discrimination, depressive symptoms and self-rated health," Social Science & Medicine, Elsevier, vol. 97(C), pages 7-14.
    6. Irene O L Wong & Benjamin J Cowling & Gabriel M Leung & C Mary Schooling, 2012. "Trends in Mortality from Septicaemia and Pneumonia with Economic Development: An Age-Period-Cohort Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-7, June.
    7. Gruenewald, Tara L. & Karlamangla, Arun S. & Hu, Perry & Stein-Merkin, Sharon & Crandall, Carolyn & Koretz, Brandon & Seeman, Teresa E., 2012. "History of socioeconomic disadvantage and allostatic load in later life," Social Science & Medicine, Elsevier, vol. 74(1), pages 75-83.
    8. Camelo, Lidyane V. & Giatti, Luana & Chor, Dóra & Griep, Rosane Härter & Benseñor, Isabela M. & Santos, Itamar S. & Kawachi, Ichiro & Barreto, Sandhi Maria, 2015. "Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)," Social Science & Medicine, Elsevier, vol. 141(C), pages 91-99.
    9. Berg, Mark T. & Simons, Ronald L. & Barr, Ashley & Beach, Steven R.H. & Philibert, Robert A., 2017. "Childhood/Adolescent stressors and allostatic load in adulthood: Support for a calibration model," Social Science & Medicine, Elsevier, vol. 193(C), pages 130-139.
    10. Anusha M Vable & Paola Gilsanz & Thu T Nguyen & Ichiro Kawachi & M Maria Glymour, 2017. "Validation of a theoretically motivated approach to measuring childhood socioeconomic circumstances in the Health and Retirement Study," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-23, October.
    11. Korous, Kevin M. & Surachman, Agus & Rogers, Charles R. & Cuevas, Adolfo G., 2023. "Parental education and epigenetic aging in middle-aged and older adults in the United States: A life course perspective," Social Science & Medicine, Elsevier, vol. 333(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dayse Rodrigues Sousa Andrade & Lidyane V. Camelo & Rodrigo Citton P. Reis & Itamar S. Santos & Antonio Luiz Ribeiro & Luana Giatti & Sandhi Maria Barreto, 2017. "Life course socioeconomic adversities and 10-year risk of cardiovascular disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(2), pages 283-292, March.
    2. Dirlam, Jonathan & Zheng, Hui, 2017. "Job satisfaction developmental trajectories and health: A life course perspective," Social Science & Medicine, Elsevier, vol. 178(C), pages 95-103.
    3. Hannes Kröger & Johan Fritzell & Rasmus Hoffmann, 2016. "The Association of Levels of and Decline in Grip Strength in Old Age with Trajectories of Life Course Occupational Position," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-16, May.
    4. Alcántara, Carmela & Chen, Chih-Nan & Alegría, Margarita, 2014. "Do post-migration perceptions of social mobility matter for Latino immigrant health?," Social Science & Medicine, Elsevier, vol. 101(C), pages 94-106.
    5. Jake M. Najman & William Wang & Maria Plotnikova & Abdullah A. Mamun & David McIntyre & Gail M. Williams & James G. Scott & William Bor & Alexandra M. Clavarino, 2020. "Poverty over the early life course and young adult cardio-metabolic risk," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(6), pages 759-768, July.
    6. Gisselmann, Marit Dahlén, 2006. "The influence of maternal childhood and adulthood social class on the health of the infant," Social Science & Medicine, Elsevier, vol. 63(4), pages 1023-1033, August.
    7. S.A. Drakopoulos & E. Lakioti & I. Theodossiou, 2011. "Childhood socioeconomic deprivation and later adulthood health," International Journal of Social Economics, Emerald Group Publishing Limited, vol. 38(1), pages 23-38, January.
    8. Sunnee Billingsley, 2019. "Intragenerational social mobility and cause-specific premature mortality," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-13, February.
    9. Morton, Patricia M. & Mustillo, Sarah A. & Ferraro, Kenneth F., 2014. "Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?," Social Science & Medicine, Elsevier, vol. 104(C), pages 133-141.
    10. Melissa Scharoun-Lee & Penny Gordon-Larsen & Linda Adair & Barry Popkin & Jay Kaufman & Chirayath Suchindran, 2011. "Intergenerational Profiles of Socioeconomic (Dis)advantage and Obesity During the Transition to Adulthood," Demography, Springer;Population Association of America (PAA), vol. 48(2), pages 625-651, May.
    11. Mazza, Julia Rachel S.E. & Lambert, Jean & Zunzunegui, Maria Victoria & Tremblay, Richard E. & Boivin, Michel & Côté, Sylvana M., 2017. "Early adolescence behavior problems and timing of poverty during childhood: A comparison of lifecourse models," Social Science & Medicine, Elsevier, vol. 177(C), pages 35-42.
    12. Singh-Manoux, Archana & Gourmelen, Julie & Ferrie, Jane & Silventoinen, Karri & Guéguen, Alice & Stringhini, Silvia & Nabi, Hermann & Kivimaki, Mika, 2010. "Trends in the association between height and socioeconomic indicators in France, 1970-2003," Economics & Human Biology, Elsevier, vol. 8(3), pages 396-404, December.
    13. Darin-Mattsson, Alexander & Andel, Ross & Celeste, Roger Keller & Kåreholt, Ingemar, 2018. "Linking financial hardship throughout the life-course with psychological distress in old age: Sensitive period, accumulation of risks, and chain of risks hypotheses," Social Science & Medicine, Elsevier, vol. 201(C), pages 111-119.
    14. Elovainio, Marko & Kivimäki, Mika & Ek, Ellen & Vahtera, Jussi & Honkonen, Teija & Taanila, Anja & Veijola, Juha & Järvelin, Marjo-Riitta, 2007. "The effect of pre-employment factors on job control, job strain and psychological distress: A 31-year longitudinal study," Social Science & Medicine, Elsevier, vol. 65(2), pages 187-199, July.
    15. Riser, Quentin H. & Rouse, Heather L. & Dorius, Cassandra J., 2023. "Association between early income variation around poverty thresholds, income trajectories, and birth, child, and family characteristics," Children and Youth Services Review, Elsevier, vol. 145(C).
    16. Elwell-Sutton, Timothy M. & Jiang, Chao Qiang & Zhang, Wei Sen & Cheng, Kar Keung & Lam, Tai Hing & Leung, Gabriel M. & Schooling, C.M., 2011. "Socioeconomic influences at different life stages on health in Guangzhou, China," Social Science & Medicine, Elsevier, vol. 72(11), pages 1884-1892, June.
    17. Kristensen, Petter & Bjerkedal, Tor & Irgens, Lorentz M., 2007. "Early life determinants of musculoskeletal sickness absence in a cohort of Norwegians born in 1967-1976," Social Science & Medicine, Elsevier, vol. 64(3), pages 646-655, February.
    18. Lemelin, Emily T. & Diez Roux, Ana V. & Franklin, Tracy G. & Carnethon, Mercedes & Lutsey, Pamela L. & Ni, Hanyu & O'Meara, Ellen & Shrager, Sandi, 2009. "Life-course socioeconomic positions and subclinical atherosclerosis in the multi-ethnic study of atherosclerosis," Social Science & Medicine, Elsevier, vol. 68(3), pages 444-451, February.
    19. Glass, Thomas A. & McAtee, Matthew J., 2006. "Behavioral science at the crossroads in public health: Extending horizons, envisioning the future," Social Science & Medicine, Elsevier, vol. 62(7), pages 1650-1671, April.
    20. Lee, Miaw-Chwen & Huang, Nicole, 2015. "Changes in self-perceived economic satisfaction and mortality at old ages: Evidence from a survey of middle-aged and elderly adults in Taiwan," Social Science & Medicine, Elsevier, vol. 130(C), pages 1-8.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:socmed:v:71:y:2010:i:1:p:187-195. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/315/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.