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Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

Author

Listed:
  • Rodrigo B Mansur
  • Graccielle R Cunha
  • Elson Asevedo
  • André Zugman
  • Maiara Zeni-Graiff
  • Adiel C Rios
  • Sumit Sethi
  • Pawan K Maurya
  • Mateus L Levandowski
  • Ary Gadelha
  • Pedro M Pan
  • Laura Stertz
  • Síntia I Belangero
  • Márcia Kauer-Sant' Anna
  • Antônio L Teixeira
  • Jair J Mari
  • Luis A Rohde
  • Euripedes C Miguel
  • Roger S McIntyre
  • Rodrigo Grassi-Oliveira
  • Rodrigo A Bressan
  • Elisa Brietzke

Abstract

Background: Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings: Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077). SED was also significantly associated with all CBCL DSM-oriented scales (all p

Suggested Citation

  • Rodrigo B Mansur & Graccielle R Cunha & Elson Asevedo & André Zugman & Maiara Zeni-Graiff & Adiel C Rios & Sumit Sethi & Pawan K Maurya & Mateus L Levandowski & Ary Gadelha & Pedro M Pan & Laura Stert, 2016. "Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0160455
    DOI: 10.1371/journal.pone.0160455
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    References listed on IDEAS

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    3. Silvia Stringhini & G David Batty & Pascal Bovet & Martin J Shipley & Michael G Marmot & Meena Kumari & Adam G Tabak & Mika Kivimäki, 2013. "Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study," PLOS Medicine, Public Library of Science, vol. 10(7), pages 1-15, July.
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