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Genetic Variant in MTRR, but Not MTR, Is Associated with Risk of Congenital Heart Disease: An Integrated Meta-Analysis

Author

Listed:
  • Bingxi Cai
  • Ti Zhang
  • Rong Zhong
  • Li Zou
  • Beibei Zhu
  • Wei Chen
  • Na Shen
  • Juntao Ke
  • Jiao Lou
  • Zhenling Wang
  • Yu Sun
  • Lifeng Liu
  • Ranran Song

Abstract

Background: Congenital heart disease (CHD) is one of the most common birth defects and the leading cause of deaths among individuals with congenital structural abnormalities worldwide. Both Methionine synthase reductase (MTRR) and Methionine synthase (MTR) are key enzymes involved in the metabolic pathway of homocysteine, which are significant in the earlier period embryogenesis, particularly in the cardiac development. Evidence is mounting for the association between MTRR A66G (rs1801394)/MTR A2756G (rs1805087) and the CHD risk, but results are controversial. Therefore, we conducted a meta-analysis integrating case-control and transmitted disequilibrium test (TDT) studies to obtain more precise estimate of the associations of these two variants with the CHD risk. Methods: To combine case-control and TDT studies, we used the Catmap package of R software to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 9 reports were included in the final meta-analysis. Eight of them comprised of 914 cases, 964 controls, and 441 families that were germane to MTRR A66G polymorphism; and 4 reports comprised of 250 cases, 205 controls, and 53 families that were relevant to MTR A2756G polymorphism. The pooled OR for the MTRR 66 G allele versus A allele was 1.35 (95% CI = 1.14–1.59, P

Suggested Citation

  • Bingxi Cai & Ti Zhang & Rong Zhong & Li Zou & Beibei Zhu & Wei Chen & Na Shen & Juntao Ke & Jiao Lou & Zhenling Wang & Yu Sun & Lifeng Liu & Ranran Song, 2014. "Genetic Variant in MTRR, but Not MTR, Is Associated with Risk of Congenital Heart Disease: An Integrated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0089609
    DOI: 10.1371/journal.pone.0089609
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    References listed on IDEAS

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    2. Benoit G. Bruneau, 2008. "The developmental genetics of congenital heart disease," Nature, Nature, vol. 451(7181), pages 943-948, February.
    3. Qibin Song & Beibei Zhu & Weiguo Hu & Liming Cheng & Hongyun Gong & Bin Xu & Xiawen Zheng & Li Zou & Rong Zhong & Shengyu Duan & Wei Chen & Rui Rui & Jing Wu & Xiaoping Miao, 2012. "A Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-8, March.
    4. Aurelio Tobias, 1999. "Assessing the influence of a single study in the meta-anyalysis estimate," Stata Technical Bulletin, StataCorp LP, vol. 8(47).
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