IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0041546.html
   My bibliography  Save this article

Association of MDM2 SNP309 Variation with Lung Cancer Risk: Evidence from 7196 Cases and 8456 Controls

Author

Listed:
  • Wenlei Zhuo
  • Liang Zhang
  • Bo Zhu
  • Junjun Ling
  • Zhengtang Chen

Abstract

Background: Evidence suggests that MDM2 T309G polymorphism may be a risk factor for several cancers. Increasing investigations have been conducted on the association of MDM2 T309G polymorphisms with lung cancer risk and have yielded conflicting results. Previous meta-analyses on this issue have reported inconclusive data. The aim of the present study was to derive a more precise estimation of the relationship. Methods and Findings: Updated meta-analyses examining the association between MDM2 T309G polymorphism and lung cancer risk were performed. Separate analyses on ethnicity, smoking status, histological types and gender as well as source of controls were also implemented. Eligible studies were identified for the period up to Feb 2012. Lastly, ten publications including eleven case-control studies were selected for analysis. The overall data failed to indicate a significant association between MDM2 T309G polymorphism and lung cancer risk (GG vs TT OR = 1.14; 95%CI = 0.95−1.37; dominant model: OR = 1.05; 95%CI = 0.92−1.19; recessive model: OR = 1.12; 95%CI = 0.99−1.27). In a subgroup analysis by smoking status, increased lung cancer risk was shown among never-smokers (GG vs TT: OR = 1.76; 95%CI = 1.36−2.29; dominant model: OR = 1.48; 95%CI = 1.22−1.81; recessive model: OR = 1.37; 95%CI = 1.11−1.69). In subgroup analysis by gender, elevated risk was presented among women under a recessive model (OR = 1.29; 95%CI = 1.04−1.59). In the subgroup analysis by ethnicity, histological types and source of controls, no marked associations were observed. Conclusions: Compared to the previous meta-analyses, the results of this study confirmed that MDM2 T309G polymorphism might be a risk factor for lung cancer among never-smokers. However, the data failed to suggest a marked association between the G allele of MDM2 T309G and lung cancer risk among Asians. More interestingly, subgroup analysis by gender indicated that homozygous GG alleles might raise lung cancer risk among females.

Suggested Citation

  • Wenlei Zhuo & Liang Zhang & Bo Zhu & Junjun Ling & Zhengtang Chen, 2012. "Association of MDM2 SNP309 Variation with Lung Cancer Risk: Evidence from 7196 Cases and 8456 Controls," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0041546
    DOI: 10.1371/journal.pone.0041546
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041546
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041546&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0041546?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Aurelio Tobias, 1999. "Assessing the influence of a single study in the meta-anyalysis estimate," Stata Technical Bulletin, StataCorp LP, vol. 8(47).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fanjie Meng & Xiangpo Pan & Wenzhen Tong, 2018. "Rifampicin versus streptomycin for brucellosis treatment in humans: A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-12, February.
    2. Mekonnen Sisay & Dumessa Edessa & Tilahun Ali & Abraham Nigussie Mekuria & Alemu Gebrie, 2020. "The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-20, October.
    3. Meiyun Wang & Xiubo Jiang & Wenlong Wu & Dongfeng Zhang, 2013. "Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-9, March.
    4. Jennifer S. Wong & Chelsey Lee & Natalie Beck, 2024. "The effects of aftercare/resettlement services on crime and violence in children and youth: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 20(2), June.
    5. Doris S M Chan & Rosa Lau & Dagfinn Aune & Rui Vieira & Darren C Greenwood & Ellen Kampman & Teresa Norat, 2011. "Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-11, June.
    6. Dongdong Xiao & Xin Nie & Wenyue Wang & Juan Zhou & Ming Zhang & Zhe Zhou & Yang Zhao & Meng Gu & Zhong Wang & Mujun Lu, 2014. "Comparison of Transverse Island Flap Onlay and Tubularized Incised-Plate Urethroplasties for Primary Proximal Hypospadias: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-10, September.
    7. SiJie Liu & Lei Yao & DongLin Ding & HuanZhang Zhu, 2010. "CCL3L1 Copy Number Variation and Susceptibility to HIV-1 Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-7, December.
    8. Bijing Mao & Yafei Li & Zhimin Zhang & Chuan Chen & Yuanyuan Chen & Chenchen Ding & Lin Lei & Jian Li & Mei Jiang & Dong Wang & Ge Wang, 2015. "One-Carbon Metabolic Factors and Risk of Renal Cell Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-10, October.
    9. Jennifer S. Wong & Chelsey Lee & Natalie Beck, 2023. "PROTOCOL: The effects of resettlement/re‐entry services on crime and violence in children and youth: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 19(1), March.
    10. Qian Chen & Rongliang Shi & Weiyan Liu & Daowen Jiang, 2013. "Assessing Interactions between the Association of Common Genetic Variant at 1p11 (rs11249433) and Hormone Receptor Status with Breast Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
    11. Rui Rui & Jiao Lou & Li Zou & Rong Zhong & Ji Wang & Ding Xia & Qi Wang & Heng Li & Jing Wu & Xuzai Lu & Chuanqi Li & Li Liu & Jiahong Xia & Hua Xu, 2012. "Excess Body Mass Index and Risk of Liver Cancer: A Nonlinear Dose-Response Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    12. Le Zhuang & Weiyuan Ma & Daxing Cai & Hua Zhong & Qing Sun, 2013. "Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    13. Yaxuan Sun & Yongxia Ding & Kun Meng & Bin Han & Jing Wang & Yan Han, 2021. "Comparison the effects of carotid endarterectomy with carotid artery stenting for contralateral carotid occlusion," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-13, May.
    14. Meng-Ni Wu & Ping-Tao Tseng & Tien-Yu Chen & Yen-Wen Chen & Li-Min Liou & Pao-Yen Lin & Chung-Yao Hsu, 2018. "The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-15, April.
    15. Dongmei Shi & Han Chan & Xia Yang & Gaofu Zhang & Haiping Yang & Mo Wang & Qiu Li, 2019. "Risk factors associated with IgA vasculitis with nephritis (Henoch–Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-15, October.
    16. Libing Wang & Fan Yin & Xia Xu & Xiaoxia Hu & Dongbao Zhao, 2012. "X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    17. Chi Zhang & Zhi-Yong Wang & Ying-Yi Qin & Fei-Fei Yu & Yu-Hao Zhou, 2014. "Association between B Vitamins Supplementation and Risk of Cardiovascular Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-13, September.
    18. Bingxi Cai & Ti Zhang & Rong Zhong & Li Zou & Beibei Zhu & Wei Chen & Na Shen & Juntao Ke & Jiao Lou & Zhenling Wang & Yu Sun & Lifeng Liu & Ranran Song, 2014. "Genetic Variant in MTRR, but Not MTR, Is Associated with Risk of Congenital Heart Disease: An Integrated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    19. Li-Yuan Liu & Meng Wang & Zhong-Bing Ma & Li-Xiang Yu & Qiang Zhang & De-Zong Gao & Fei Wang & Zhi-Gang Yu, 2013. "The Role of Adiponectin in Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    20. Haolin Wang & Wendy Y. Huang & Yanan Zhao, 2022. "Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(13), pages 1-16, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0041546. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.