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The developmental genetics of congenital heart disease

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  • Benoit G. Bruneau

    (Gladstone Institute of Cardiovascular Disease, University of California San Francisco)

Abstract

Congenital heart disease is the leading cause of infant morbidity in the Western world, but only in the past ten years has its aetiology been understood. Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease.

Suggested Citation

  • Benoit G. Bruneau, 2008. "The developmental genetics of congenital heart disease," Nature, Nature, vol. 451(7181), pages 943-948, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06801
    DOI: 10.1038/nature06801
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    Cited by:

    1. Hsiao-Ling Yang & Ya-Ling Yang & Chong Ho Yu & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis," IJERPH, MDPI, vol. 15(8), pages 1-18, August.
    2. Bingxi Cai & Ti Zhang & Rong Zhong & Li Zou & Beibei Zhu & Wei Chen & Na Shen & Juntao Ke & Jiao Lou & Zhenling Wang & Yu Sun & Lifeng Liu & Ranran Song, 2014. "Genetic Variant in MTRR, but Not MTR, Is Associated with Risk of Congenital Heart Disease: An Integrated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    3. Carmen Sena-Tomás & Angelika G. Aleman & Caitlin Ford & Akriti Varshney & Di Yao & Jamie K. Harrington & Leonor Saúde & Mirana Ramialison & Kimara L. Targoff, 2022. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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