IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0075658.html
   My bibliography  Save this article

Trends and Significance of VRE Colonization in the ICU: A Meta-Analysis of Published Studies

Author

Listed:
  • Panayiotis D Ziakas
  • Rachana Thapa
  • Louis B Rice
  • Eleftherios Mylonakis

Abstract

Background: The burden and significance of vancomycin-resistant enterococci (VRE) colonization in the ICU is not clearly understood. Methods: We searched PubMed and EMBASE up to May 2013 for studies reporting the prevalence of VRE upon admission to the ICU and performed a meta-analysis to assess rates and trends of VRE colonization. We calculated the prevalence of VRE on admission and the acquisition (colonization and/or infection) rates to estimate time trends and the impact of colonization on ensuing VRE infections. Findings: Across 37 studies (62,959 patients at risk), the estimated prevalence of VRE on admission to the ICU was 8.8% (7.1-10.6). Estimates were more consistent when cultures were obtained within 24 hours from admission. The VRE acquisition rate was 8.8% (95% CI 6.9-11.0) across 26 evaluable studies (35,364 patients at risk). Across US studies, VRE acquisition rate was 10.2% (95% CI 7.7-13.0) and demonstrated significant decline in annual trends. We used the US estimate of colonization on admission [12.3% (10.5-14.3)] to evaluate the impact of VRE colonization on admission in overall VRE prevalence. We demonstrated that VRE colonization on admission is a major determinant of the overall VRE burden in the ICU. Importantly, among colonized patients (including admitted and/or acquired cases) the VRE infection rates vary widely from 0-45% (with the risk of VRE bacteremia being reported from 0-16%) and

Suggested Citation

  • Panayiotis D Ziakas & Rachana Thapa & Louis B Rice & Eleftherios Mylonakis, 2013. "Trends and Significance of VRE Colonization in the ICU: A Meta-Analysis of Published Studies," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    • Handle: RePEc:plo:pone00:0075658
    DOI: 10.1371/journal.pone.0075658
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075658
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075658&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0075658?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sukanta Saha & David Chant & Joy Welham & John McGrath, 2005. "A Systematic Review of the Prevalence of Schizophrenia," PLOS Medicine, Public Library of Science, vol. 2(5), pages 1-1, May.
    2. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Viktoria Maria Baumeister & Leonie Petra Kuen & Maike Bruckes & Gerhard Schewe, 2021. "The Relationship of Work-Related ICT Use With Well-being, Incorporating the Role of Resources and Demands: A Meta-Analysis," SAGE Open, , vol. 11(4), pages 21582440211, November.
    2. Lianjie Liu & Zhuo Shao & Hang Yu & Wei Zhang & Hao Wang & Zubing Mei, 2020. "Is the platelet to lymphocyte ratio a promising biomarker to distinguish acute appendicitis? Evidence from a systematic review with meta-analysis," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-15, May.
    3. Ioana A Cristea & Robin N Kok & Pim Cuijpers, 2016. "The Effectiveness of Cognitive Bias Modification Interventions for Substance Addictions: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-19, September.
    4. Je-Young Lee & Minkyung Baek, 2023. "Effects of Gamification on Students’ English Language Proficiency: A Meta-Analysis on Research in South Korea," Sustainability, MDPI, vol. 15(14), pages 1-19, July.
    5. Martin Polak & Norbert Tanzer & Per Carlbring, 2022. "PROTOCOL: Effects of virtual reality exposure therapy versus in vivo exposure in treating social anxiety disorder in adults: A systematic review and meta‐analysis," Campbell Systematic Reviews, John Wiley & Sons, vol. 18(3), September.
    6. Muthanna Samara & Bruna Da Silva Nascimento & Aiman El-Asam & Sara Hammuda & Nabil Khattab, 2021. "How Can Bullying Victimisation Lead to Lower Academic Achievement? A Systematic Review and Meta-Analysis of the Mediating Role of Cognitive-Motivational Factors," IJERPH, MDPI, vol. 18(5), pages 1-21, February.
    7. Zhao-Feng Chen & Lufei Young & Chong Ho Yu & S. Pamela K. Shiao, 2018. "A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide," IJERPH, MDPI, vol. 15(7), pages 1-16, July.
    8. Chun-Yu Chang & Po-Chen Lin & Yung-Jiun Chien & Chien-Sheng Chen & Meng-Yu Wu, 2020. "Analysis of Chest-Compression Depth and Full Recoil in Two Infant Chest-Compression Techniques Performed by a Single Rescuer: Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(11), pages 1-17, June.
    9. Mohith M. Varma & Shengzi Zeng & Laura Singh & Emily A. Holmes & Jingyun Huang & Man Hey Chiu & Xiaoqing Hu, 2024. "A systematic review and meta-analysis of experimental methods for modulating intrusive memories following lab-analogue trauma exposure in non-clinical populations," Nature Human Behaviour, Nature, vol. 8(10), pages 1968-1987, October.
    10. Woodley of Menie, Michael A. & Peñaherrera-Aguirre, Mateo & Sarraf, Matthew A., 2022. "Signs of a Flynn effect in rodents? Secular differentiation of the manifold of general cognitive ability in laboratory mice (Mus musculus) and Norwegian rats (Rattus norvegicus) over a century—Results," Intelligence, Elsevier, vol. 95(C).
    11. Teresa Del Giudice & Carla Cavallo & Francesco Caracciolo & Gianni Cicia, 2015. "What attributes of extra virgin olive oil are really important for consumers: a meta-analysis of consumers’ stated preferences," Agricultural and Food Economics, Springer;Italian Society of Agricultural Economics (SIDEA), vol. 3(1), pages 1-15, December.
    12. Beaulieu, Myriam & Tremblay, Joël & Baudry, Claire & Pearson, Jessica & Bertrand, Karine, 2021. "A systematic review and meta-analysis of the efficacy of the long-term treatment and support of substance use disorders," Social Science & Medicine, Elsevier, vol. 285(C).
    13. Se Young Kim & Mi-Kyoung Cho, 2022. "The Effect of Nurse Support Programs on Job Satisfaction and Organizational Behaviors among Hospital Nurses: A Meta-Analysis," IJERPH, MDPI, vol. 19(24), pages 1-23, December.
    14. Trood, Michael D. & Spivak, Benjamin L. & Ogloff, James R.P., 2021. "A systematic review and meta-analysis of the effects of judicial supervision on recidivism and well-being factors of criminal offenders," Journal of Criminal Justice, Elsevier, vol. 74(C).
    15. Sergio Nolazco & Kaspar Delhey & Shinichi Nakagawa & Anne Peters, 2022. "Ornaments are equally informative in male and female birds," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    16. Kylee Trevillion & Siân Oram & Gene Feder & Louise M Howard, 2012. "Experiences of Domestic Violence and Mental Disorders: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-12, December.
    17. Xin Zhang & Bai Gao & Bing Xu, 2020. "No association between the vitamin D-binding protein (DBP) gene polymorphisms (rs7041 and rs4588) and multiple sclerosis and type 1 diabetes mellitus: A meta-analysis," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-10, November.
    18. Yucheon Kim & Songyi Lee, 2023. "A Systematic Review and Meta-Analysis of the Effectiveness of Non-Face-to-Face Coaching," Sustainability, MDPI, vol. 15(12), pages 1-15, June.
    19. Ferrero, Marta & Vadillo, Miguel A. & León, Samuel P., 2021. "A valid evaluation of the theory of multiple intelligences is not yet possible: Problems of methodological quality for intervention studies," Intelligence, Elsevier, vol. 88(C).
    20. Ivan Ropovik & Matus Adamkovic & David Greger, 2021. "Neglect of publication bias compromises meta-analyses of educational research," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-14, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0075658. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.