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Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance

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  • Xiuying Zhang
  • Dongqian Shen
  • Zhiwei Fang
  • Zhuye Jie
  • Xinmin Qiu
  • Chunfang Zhang
  • Yingli Chen
  • Linong Ji

Abstract

To explore the relationship of gut microbiota with the development of type 2 diabetes (T2DM), we analyzed 121 subjects who were divided into 3 groups based on their glucose intolerance status: normal glucose tolerance (NGT; n = 44), prediabetes (Pre-DM; n = 64), or newly diagnosed T2DM (n = 13). Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. T2DM-related dysbiosis was observed, including the separation of microbial communities and a change of alpha diversity between the different glucose intolerance statuses. To assess the correlation between metabolic parameters and microbiota diversity, clinical characteristics were also measured and a significant association between metabolic parameters (FPG, CRP) and gut microbiota was found. In addition, a total of 28 operational taxonomic units (OTUs) were found to be related to T2DM status by the Kruskal-Wallis H test, most of which were enriched in the T2DM group. Butyrate-producing bacteria (e.g. Akkermansia muciniphila ATCCBAA-835, and Faecalibacterium prausnitzii L2-6) had a higher abundance in the NGT group than in the pre-DM group. At genus level, the abundance of Bacteroides in the T2DM group was only half that of the NGT and Pre-DM groups. Previously reported T2DM-related markers were also compared with the data in this study, and some inconsistencies were noted. We found that Verrucomicrobiae may be a potential marker of T2DM as it had a significantly lower abundance in both the pre-DM and T2DM groups. In conclusion, this research provides further evidence of the structural modulation of gut microbiota in the pathogenesis of diabetes.

Suggested Citation

  • Xiuying Zhang & Dongqian Shen & Zhiwei Fang & Zhuye Jie & Xinmin Qiu & Chunfang Zhang & Yingli Chen & Linong Ji, 2013. "Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0071108
    DOI: 10.1371/journal.pone.0071108
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    References listed on IDEAS

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    2. Fredrik H. Karlsson & Frida Fåk & Intawat Nookaew & Valentina Tremaroli & Björn Fagerberg & Dina Petranovic & Fredrik Bäckhed & Jens Nielsen, 2012. "Symptomatic atherosclerosis is associated with an altered gut metagenome," Nature Communications, Nature, vol. 3(1), pages 1-8, January.
    3. Peter J. Turnbaugh & Ruth E. Ley & Michael A. Mahowald & Vincent Magrini & Elaine R. Mardis & Jeffrey I. Gordon, 2006. "An obesity-associated gut microbiome with increased capacity for energy harvest," Nature, Nature, vol. 444(7122), pages 1027-1031, December.
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    1. Zahraa Al Bander & Marloes Dekker Nitert & Aya Mousa & Negar Naderpoor, 2020. "The Gut Microbiota and Inflammation: An Overview," IJERPH, MDPI, vol. 17(20), pages 1-21, October.
    2. Alessandra N. Bazzano & Kaitlin S. Potts & Lydia A. Bazzano & John B. Mason, 2017. "The Life Course Implications of Ready to Use Therapeutic Food for Children in Low-Income Countries," IJERPH, MDPI, vol. 14(4), pages 1-19, April.
    3. Pablo Villoslada-Blanco & Patricia Pérez-Matute & José A. Oteo, 2021. "Lights and Shadows of Microbiota Modulation and Cardiovascular Risk in HIV Patients," IJERPH, MDPI, vol. 18(13), pages 1-24, June.

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