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Symptomatic atherosclerosis is associated with an altered gut metagenome

Author

Listed:
  • Fredrik H. Karlsson

    (Chalmers University of Technology)

  • Frida Fåk

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg
    Center for Cardiovascular and Metabolic Research)

  • Intawat Nookaew

    (Chalmers University of Technology
    Center for Cardiovascular and Metabolic Research)

  • Valentina Tremaroli

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg
    Center for Cardiovascular and Metabolic Research)

  • Björn Fagerberg

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg
    Center for Cardiovascular and Metabolic Research)

  • Dina Petranovic

    (Chalmers University of Technology)

  • Fredrik Bäckhed

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg
    Center for Cardiovascular and Metabolic Research)

  • Jens Nielsen

    (Chalmers University of Technology)

Abstract

Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls. Further characterization of the functional capacity of the metagenomes revealed that patient gut metagenomes were enriched in genes encoding peptidoglycan synthesis and depleted in phytoene dehydrogenase; patients also had reduced serum levels of β-carotene. Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome.

Suggested Citation

  • Fredrik H. Karlsson & Frida Fåk & Intawat Nookaew & Valentina Tremaroli & Björn Fagerberg & Dina Petranovic & Fredrik Bäckhed & Jens Nielsen, 2012. "Symptomatic atherosclerosis is associated with an altered gut metagenome," Nature Communications, Nature, vol. 3(1), pages 1-8, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2266
    DOI: 10.1038/ncomms2266
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    Cited by:

    1. Gertrude Ecklu-Mensah & Candice Choo-Kang & Maria Gjerstad Maseng & Sonya Donato & Pascal Bovet & Bharathi Viswanathan & Kweku Bedu-Addo & Jacob Plange-Rhule & Prince Oti Boateng & Terrence E. Forrest, 2023. "Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Vinod Nikhra, 2019. "The Novel Dimensions of Cardio-Metabolic Health Gut Microbiota, Dysbiosis and its Fallouts," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 11(1), pages 28-37, June.
    3. Xiuying Zhang & Dongqian Shen & Zhiwei Fang & Zhuye Jie & Xinmin Qiu & Chunfang Zhang & Yingli Chen & Linong Ji, 2013. "Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-11, August.

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