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IL-10 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis

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  • Ping Liu
  • Jianwen Song
  • Hui Su
  • Linli Li
  • Ning Lu
  • Rongli Yang
  • Zhenhui Peng

Abstract

Background: A number of observational studies have been conducted to investigate the association of the IL-10 gene polymorphisms with systemic lupus erythematosus (SLE) susceptibility. However, their results are conflicting. Method: We searched published case-control studies on the IL-10 polymorphisms and SLE in PubMed, EMBASE and Chinese Biomedical Literature Database. A meta-analysis was conducted using a fixed-effect or random-effect model based on between-study heterogeneity. Results: A total of 42 studies with 7948 cases and 11866 controls were included in this meta-analysis. Among Caucasians, the CA27 allele of the IL10.G microsatellites (OR 2.38, 95% CI 1.01–5.62), the G allele of the IL-10 -1082G/A polymorphism (G vs. A: OR 1.21, 95% CI 1.02–1.44; GG vs. AA: OR 1.45, 95% CI 1.16–1.82; GG+GA vs. AA: OR 1.16, 95% CI 1.03–1.29) and its associated haplotype -1082G/−819C/−592C (OR 1.25, 95% CI 1.10–1.42) were associated with increased SLE susceptibility without or with unimportant between-study heterogeneity. Removing studies deviating from Hardy-Weinberg equilibrium (HWE) hardly changed these results. Among Asians, the CA21 allele of the IL-10.G microsatellites (OR 1.28, 95% CI 1.02–1.60) and the -1082G/−819C/−592C haplotype (OR 1.24, 95% CI 1.00–1.53) were associated with increased SLE susceptibility, but with substantial between-study heterogeneity or sensitive to HWE status. Removing studies deviating from HWE also produced statistically significant associations of the IL-10 -1082G/A (GG vs. AA: OR 3.21, 95% CI 1.24–8.28; GG vs. AA+GA: OR 2.85, 95% CI 1.19–6.79) and -592C/A polymorphisms (CC+CA vs. AA: OR 0.69, 95% CI 0.51–0.94) with SLE among Asians. Conclusion: This meta-analysis showed that the IL10.G microsatellites, the IL-10 -1082G/A and -592C/A polymorphisms and the haplotype -1082G/−819C/−592C are associated with SLE susceptibility. Besides, this is the first time to report an association between the CA27 allele of the IL-10.G microsatellites and SLE among Caucasians. Further studies are needed to confirm these findings.

Suggested Citation

  • Ping Liu & Jianwen Song & Hui Su & Linli Li & Ning Lu & Rongli Yang & Zhenhui Peng, 2013. "IL-10 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0069547
    DOI: 10.1371/journal.pone.0069547
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    References listed on IDEAS

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    1. Zhenglun Pan & Thomas A Trikalinos & Fotini K Kavvoura & Joseph Lau & John PA Ioannidis, 2005. "Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature," PLOS Medicine, Public Library of Science, vol. 2(12), pages 1-1, November.
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    1. Xuan Gao & Junjun Chen & Zhongkai Tong & Guangdie Yang & Yinan Yao & Fei Xu & Jianying Zhou, 2015. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.

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