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Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis

Author

Listed:
  • Xuan Gao
  • Junjun Chen
  • Zhongkai Tong
  • Guangdie Yang
  • Yinan Yao
  • Fei Xu
  • Jianying Zhou

Abstract

Objective: As an update to other recent meta-analyses, the purpose of this study was to explore whether interleukin-10 (IL-10) polymorphisms and their haplotypes contribute to tuberculosis (TB) susceptibility. Methods: We searched for published case-control studies examining IL-10 polymorphisms and TB in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wanfang databases and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strengths of the associations. Results: A total of 28 studies comprising 8,242 TB patients and 9,666 controls were included in the present study. There were no significant associations between the -1082G/A, -819C/T, and -592A/C polymorphisms and TB in the pooled samples. Subgroup analyses revealed that the -819T allele was associated with an increased TB risk in Asians in all genetic models (T vs. C: OR=1.17, 95% CI=1.05-1.29, P=0.003; TT vs. CC: OR=1.37, 95% CI=1.09-1.72, P=0.006; CT+TT vs. CC: OR=1.33, 95% CI=1.09-1.63, P=0.006; TT vs. CT+CC: OR=1.17, 95% CI=1.02-1.35, P=0.03) and that the -592A/C polymorphism was significantly associated with TB in Europeans under two genetic models (A vs. C: OR=0.77, 95% CI=0.60-0.98, P=0.03; AA vs. CC: OR=0.53, 95% CI=0.30-0.95, P=0.03). Furthermore, the GCC IL-10 promoter haplotype was associated with an increased risk of TB (GCC vs. others: P=1.42, 95% CI=1.02-1.97, P=0.04). Subgroup analyses based on ethnicity revealed that the GCC haplotype was associated with a higher risk of TB in Europeans, whereas the ACC haplotype was associated with a lower TB risk in both Asians and Europeans. Conclusions: This meta-analysis suggests that the IL-10-819T/C polymorphism is associated with the risk of TB in Asians and that the IL-10-592A/C polymorphism may be a risk factor for TB in Europeans. Furthermore, these data indicate that IL-10 promoter haplotypes play a vital role in the susceptibility to or protection against the development of TB.

Suggested Citation

  • Xuan Gao & Junjun Chen & Zhongkai Tong & Guangdie Yang & Yinan Yao & Fei Xu & Jianying Zhou, 2015. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0127496
    DOI: 10.1371/journal.pone.0127496
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    References listed on IDEAS

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    1. Ping Liu & Jianwen Song & Hui Su & Linli Li & Ning Lu & Rongli Yang & Zhenhui Peng, 2013. "IL-10 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    2. Bin Liang & Yang Guo & Yunhui Li & Hong Kong, 2014. "Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-10, February.
    3. Myung-Han Hyun & Chung-Ho Lee & Min-Hyung Kang & Bong-Kyung Park & Young Ho Lee, 2013. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    4. Jia-Jia Wang & Xian Xia & Shai-Di Tang & Jie Wang & Xiao-Zhao Deng & Yun Zhang & Ming Yue, 2013. "Meta-Analysis on the Associations of TLR2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility among Asian Populations," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-6, October.
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