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Meta-Analysis of Microsomal Epoxide Hydrolase Gene Polymorphism and Risk of Hepatocellular Carcinoma

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  • Jian-Hong Zhong
  • Bang-De Xiang
  • Liang Ma
  • Xue-Mei You
  • Le-Qun Li
  • Gui-Sheng Xie

Abstract

Background: Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in microsomal epoxide hydrolase (mEH). Previous work suggests an association between the Tyr113His and His139Arg mEH polymorphisms and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent. Methods: PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between Tyr113His and His139Arg mEH polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results: Eleven studies were included in the meta-analysis, involving 1,696 HCC cases and 3,600 controls. The 113His- mEH allele was significantly associated with increased risk of HCC based on allelic contrast (OR = 1.35, 95% CI = 1.04–1.75, p = 0.02), homozygote comparison (OR = 1.65, 95% CI = 1.07–2.54, p = 0.02) and a recessive genetic model (OR = 1.54, 95% CI = 1.21–1.96, p

Suggested Citation

  • Jian-Hong Zhong & Bang-De Xiang & Liang Ma & Xue-Mei You & Le-Qun Li & Gui-Sheng Xie, 2013. "Meta-Analysis of Microsomal Epoxide Hydrolase Gene Polymorphism and Risk of Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0057064
    DOI: 10.1371/journal.pone.0057064
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    References listed on IDEAS

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    1. Jian-Hong Zhong & Xue-Mei You & Wen-Feng Gong & Liang Ma & Yu Zhang & Qin-Guo Mo & Liu-Cheng Wu & Jun Xiao & Le-Qun Li, 2012. "Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-8, March.
    2. Zhenglun Pan & Thomas A Trikalinos & Fotini K Kavvoura & Joseph Lau & John PA Ioannidis, 2005. "Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature," PLOS Medicine, Public Library of Science, vol. 2(12), pages 1-1, November.
    3. Xiang Li & Zheng Hu & Xinshun Qu & Jiadong Zhu & Lin Li & Brian Z Ring & Li Su, 2011. "Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers: A Comprehensive Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-12, March.
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    1. Hong Chen & Lin Ge & Qiuli Sui & Mei Lin, 2015. "Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.

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