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Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis

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  • Huadan Ye
  • Annan Zhou
  • Qiangxiao Hong
  • Linlin Tang
  • Xuting Xu
  • Yanfei Xin
  • Danjie Jiang
  • Dongjun Dai
  • Yirun Li
  • Dao Wen Wang
  • Shiwei Duan

Abstract

Objective: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. Methods: We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software. Results: Significant differences were observed between CHD cases and controls at the level of both genotype (χ2 = 8.964, df = 2, P = 0.011) and allele (χ2 = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of APOA5 rs662799 with CHD in males (χ2 = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P

Suggested Citation

  • Huadan Ye & Annan Zhou & Qiangxiao Hong & Linlin Tang & Xuting Xu & Yanfei Xin & Danjie Jiang & Dongjun Dai & Yirun Li & Dao Wen Wang & Shiwei Duan, 2015. "Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0135683
    DOI: 10.1371/journal.pone.0135683
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    References listed on IDEAS

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    1. Zhenglun Pan & Thomas A Trikalinos & Fotini K Kavvoura & Joseph Lau & John PA Ioannidis, 2005. "Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature," PLOS Medicine, Public Library of Science, vol. 2(12), pages 1-1, November.
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