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Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature

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  • Zhenglun Pan
  • Thomas A Trikalinos
  • Fotini K Kavvoura
  • Joseph Lau
  • John PA Ioannidis

Abstract

Background: Postulated epidemiological associations are subject to several biases. We evaluated whether the Chinese literature on human genome epidemiology may offer insights on the operation of selective reporting and language biases. Methods and Findings: We targeted 13 gene-disease associations, each already assessed by meta-analyses, including at least 15 non-Chinese studies. We searched the Chinese Journal Full-Text Database for additional Chinese studies on the same topics. We identified 161 Chinese studies on 12 of these gene-disease associations; only 20 were PubMed-indexed (seven English full-text). Many studies (14–35 per topic) were available for six topics, covering diseases common in China. With one exception, the first Chinese study appeared with a time lag (2–21 y) after the first non-Chinese study on the topic. Chinese studies showed significantly more prominent genetic effects than non-Chinese studies, and 48% were statistically significant per se, despite their smaller sample size (median sample size 146 versus 268, p

Suggested Citation

  • Zhenglun Pan & Thomas A Trikalinos & Fotini K Kavvoura & Joseph Lau & John PA Ioannidis, 2005. "Local Literature Bias in Genetic Epidemiology: An Empirical Evaluation of the Chinese Literature," PLOS Medicine, Public Library of Science, vol. 2(12), pages 1-1, November.
    • Handle: RePEc:plo:pmed00:0020334
    DOI: 10.1371/journal.pmed.0020334
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    2. Ping Liu & Jianwen Song & Hui Su & Linli Li & Ning Lu & Rongli Yang & Zhenhui Peng, 2013. "IL-10 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    3. Lu Guo & Li-Li Zhang & Bo Zheng & Yun Liu & Xiao-Jie Cao & Yan Pi & Bing-Hu Li & Jing-Cheng Li, 2013. "The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-13, June.
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    6. Bo Xi & Giriraj R Chandak & Yue Shen & Qijuan Wang & Donghao Zhou, 2012. "Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    7. Jian-Hong Zhong & Bang-De Xiang & Liang Ma & Xue-Mei You & Le-Qun Li & Gui-Sheng Xie, 2013. "Meta-Analysis of Microsomal Epoxide Hydrolase Gene Polymorphism and Risk of Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.

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