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Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature

Author

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  • Kun Han
  • WeiXiang Qi
  • ZhiHua Gan
  • Zan Shen
  • Yang Yao
  • DaLiu Min

Abstract

Purpose: Ezrin is a cytoskeletal protein involved in tumor growth and invasion. However its prognostic value for survival in patients with solid tumor remains controversial. Methods: Several databases were searched, including Pubmed, Embase and Cochrane databases. The endpoints were overall survival (OS), progression-free survival (PFS). The pooled hazard ratio (HR) or odds ratio (OR), and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: Twenty-seven eligible trials involving 4693 patients were ultimately identified. A summary hazard ratio (HR) of all studies and sub-group hazard ratios were calculated. The combined HR suggested that a positive Ezrin expression had an impact on overall survival (OS) [1.95, 95% confidence interval (CI) 1.60–2.39; P

Suggested Citation

  • Kun Han & WeiXiang Qi & ZhiHua Gan & Zan Shen & Yang Yao & DaLiu Min, 2013. "Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
    • Handle: RePEc:plo:pone00:0068527
    DOI: 10.1371/journal.pone.0068527
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Yong Huang & Huaiwei Liao & Yong Zhang & Rongfa Yuan & Fengmei Wang & Yingtang Gao & Peng Wang & Zhi Du, 2014. "Prognostic Value of Tumor-Infiltrating FoxP3+ T Cells in Gastrointestinal Cancers: A Meta Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.
    2. Jian Xiao & Yong Zou & Xi Chen & Ying Gao & Mingxuan Xie & Xiaoxiao Lu & Wei Li & Bixiu He & Shuya He & Shaojin You & Qiong Chen, 2016. "The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-14, April.

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