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The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis

Author

Listed:
  • Jian Xiao
  • Yong Zou
  • Xi Chen
  • Ying Gao
  • Mingxuan Xie
  • Xiaoxiao Lu
  • Wei Li
  • Bixiu He
  • Shuya He
  • Shaojin You
  • Qiong Chen

Abstract

Background: Liver kinase B1 (LKB1) is a protein kinase that regulates the growth, integrity and polarity of mammalian cells. Recent studies have reported the prognostic value of decreased LKB1 expression in different tumors. However, the results of these studies remain controversial. Therefore, this meta-analysis was performed to more accurately estimate the role of decreased LKB1 in the prognostication of human solid tumors. Methods: A systematic literature search in the electronic databases PubMed, Embase, Web of Science and CNKI (updated to October 15, 2015) was performed to identify eligible studies. The overall survival (OS), relapse-free survival (RFS), disease-free survival (DFS) and clinicopathological features data were collected from these studies. The hazard ratios (HRs), odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and pooled with a random-effects models using Stata12.0 software. Results: A total of 14 studies covering 1915 patients with solid tumors were included in this meta-analysis. Decreased LKB1 was associated with poorer OS in both the univariate (HR: 1.86, 95%CI: 1.42–2.42, P

Suggested Citation

  • Jian Xiao & Yong Zou & Xi Chen & Ying Gao & Mingxuan Xie & Xiaoxiao Lu & Wei Li & Bixiu He & Shuya He & Shaojin You & Qiong Chen, 2016. "The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0152674
    DOI: 10.1371/journal.pone.0152674
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    References listed on IDEAS

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    1. Sophie G. Martin & Daniel St Johnston, 2003. "A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity," Nature, Nature, vol. 421(6921), pages 379-384, January.
    2. Andreas Krieg & Jasmin C Riemer & Leila A Telan & Helmut E Gabbert & Wolfram T Knoefel, 2015. "CXCR4-A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-17, June.
    3. Shu Chen Lin & Zhi Hua Gan & Yang Yao & Da Liu Min, 2015. "The Prognostic Value of Forkhead Box P3 Expression in Operable Breast Cancer: A Large-Scale Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    4. Xiangkun Han & Fuming Li & Zhaoyuan Fang & Yijun Gao & Fei Li & Rong Fang & Shun Yao & Yihua Sun & Li Li & Wenjing Zhang & Huimin Ma & Qian Xiao & Gaoxiang Ge & Jing Fang & Hongda Wang & Lei Zhang & K, 2014. "Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma," Nature Communications, Nature, vol. 5(1), pages 1-13, May.
    5. Kun Han & WeiXiang Qi & ZhiHua Gan & Zan Shen & Yang Yao & DaLiu Min, 2013. "Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
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