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Prognostic Value of Tumor-Infiltrating FoxP3+ T Cells in Gastrointestinal Cancers: A Meta Analysis

Author

Listed:
  • Yong Huang
  • Huaiwei Liao
  • Yong Zhang
  • Rongfa Yuan
  • Fengmei Wang
  • Yingtang Gao
  • Peng Wang
  • Zhi Du

Abstract

Purpose: Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression. However, its prognostic value for survival in patients with different gastrointestinal cancers [hepatocellular carcinoma (HCC), colorectal cancer (CRC), gastric cancer (GC)] remains controversial. Methods: Relevant literature was searched using PubMed, Embase, Cochrane, Ovid Medline and Chinese wanfang databases. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. The odds ratio (OR) and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Results: For HCC and GC, the overall survival at 1, 3 and 5-year of high FoxP3+ T cells infiltration patients were lower than low FoxP3+ T cells infiltration patients (P 0.05). Conclusions: Our findings suggested that tumor-infiltrating FoxP3+ T cells were a factor for a poor prognosis for HCC and GC, but a good prognosis for CRC.

Suggested Citation

  • Yong Huang & Huaiwei Liao & Yong Zhang & Rongfa Yuan & Fengmei Wang & Yingtang Gao & Peng Wang & Zhi Du, 2014. "Prognostic Value of Tumor-Infiltrating FoxP3+ T Cells in Gastrointestinal Cancers: A Meta Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0094376
    DOI: 10.1371/journal.pone.0094376
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    References listed on IDEAS

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    1. Jin Long Liu & Wei Gao & Qing Min Kang & Xue Jun Zhang & Shu Guang Yang, 2013. "Prognostic Value of Survivin in Patients with Gastric Cancer: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    2. Kun Han & WeiXiang Qi & ZhiHua Gan & Zan Shen & Yang Yao & DaLiu Min, 2013. "Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
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