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Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies

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  • Yu-jiao Wu
  • Xin Yang
  • Xiao-xiao Wang
  • Man-Tang Qiu
  • Yi-zhong You
  • Zhi-xin Zhang
  • Shan-mei Zhu
  • Lin Xu
  • Feng-lei Tang

Abstract

Background: Genetic variations in vitamin D receptor (VDR) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between VDR BsmI gene polymorphism and TB risk, but yielded inconclusive results. Methodology/Principal Findings: We performed a comprehensive meta-analysis of 15 publications with a total of 2309 cases and 3568 controls. We assessed the strength of the association between VDR BsmI gene polymorphism and TB risk and performed sub-group analyses by ethnicity, sample size and Hardy–Weinberg equilibrium (HWE). We found a statistically significant correlation between VDR BsmI gene polymorphism and decreased TB risk in four comparison models: allele model (b vs. B: OR = 0.78, 95% CI = 0.67, 0.89; Pheterogeneity = 0.004), homozygote model (bb vs. BB: OR = 0.61, 95% CI = 0.43, 0.87; Pheterogeneity = 0.001), recessive model (bb vs. Bb+BB: OR = 0.70, 95% CI = 0.56, 0.88; Pheterogeneity = 0.005) and dominant model (bb+Bb vs. BB: OR = 0.77, 95% CI = 0.61, 0.97; Pheterogeneity = 0.010), especially in studies based on Asian population. Sub-group analyses also revealed that there was a statistically decreased TB risk in “small” studies ( 0.5. Meta-regression and stratification analysis both showed that the ethnicity and sample size contributed to heterogeneity. Conclusions: This meta-analysis suggests that VDR BsmI gene polymorphism is associated with a significant decreased TB risk, especially in Asian population.

Suggested Citation

  • Yu-jiao Wu & Xin Yang & Xiao-xiao Wang & Man-Tang Qiu & Yi-zhong You & Zhi-xin Zhang & Shan-mei Zhu & Lin Xu & Feng-lei Tang, 2013. "Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0066944
    DOI: 10.1371/journal.pone.0066944
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    References listed on IDEAS

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    1. Man-Tang Qiu & Jing-Wen Hu & Xiang-Xiang Ding & Xin Yang & Zhi Zhang & Rong Yin & Lin Xu, 2012. "Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
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    Cited by:

    1. Lingling Yi & Dan Cheng & Huimin Shi & Xiaorong Huo & Kan Zhang & Guohua Zhen, 2014. "A Meta-Analysis of P2X7 Gene-762T/C Polymorphism and Pulmonary Tuberculosis Susceptibility," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.

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