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XRCC1 Arg194Trp and Arg280His Polymorphisms Increase Bladder Cancer Risk in Asian Population: Evidence from a Meta-Analysis

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  • Zhenqiang Fang
  • Fanglin Chen
  • Xiangwei Wang
  • Shanhong Yi
  • Wei Chen
  • Gang Ye

Abstract

Background: A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population. Methodology/Principal findings: The association strength was measured with odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of 9 eligible studies, conducted in China, India and Japan, were identified. We observed a significant increased risk of bladder cancer in dominant model (OR = 1.199, 95% CI: 1.021,1.408, Pheterogeneity = 0.372), allele comparison (OR = 1.200, 95% CI: 1.057,1.362, Pheterogeneity = 0.107) of Arg194Trp, heterozygote comparison (OR = 1.869, 95% CI: 1.205,2.898, Pheterogeneity = 0.011) and dominant model (OR = 1.748, 95% CI: 1.054,2.900, Pheterogeneity = 0.01) of Arg280His. Pooled results estimated from adjusted ORs further validated these findings. No publication bias was detected. Subgroup analyses found that significant increased risk was only found among community-based studies not hospital-based studies. There was no evidence of publication bias. Conclusion: This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer. Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.

Suggested Citation

  • Zhenqiang Fang & Fanglin Chen & Xiangwei Wang & Shanhong Yi & Wei Chen & Gang Ye, 2013. "XRCC1 Arg194Trp and Arg280His Polymorphisms Increase Bladder Cancer Risk in Asian Population: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-7, May.
    • Handle: RePEc:plo:pone00:0064001
    DOI: 10.1371/journal.pone.0064001
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    1. Man-Tang Qiu & Jing-Wen Hu & Xiang-Xiang Ding & Xin Yang & Zhi Zhang & Rong Yin & Lin Xu, 2012. "Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
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    1. Wei Wu & Lu Liu & Zhihua Yin & Peng Guan & Xuelian Li & Baosen Zhou, 2014. "Association of X-Ray Repair Cross-Complementing Group 1 Arg194Trp, Arg399Gln and Arg280His Polymorphisms with Head and Neck Cancer Susceptibility: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-12, January.

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