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Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis

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  • Wei Xu
  • Jijun Xu
  • Shifeng Liu
  • Bo Chen
  • Xueli Wang
  • Yan Li
  • Yun Qian
  • Weihong Zhao
  • Jianqing Wu

Abstract

Background: MicroRNAs regulate gene expression at the post-transcriptional level and involved in diverse biological and pathological processes, including tumorigenesis. Rs11614913 in miR-196a2 and rs2910164 in miR-146a are shown to associate with increased/decreased cancer risk. We performed a meta-analysis to systematically summarize the possible association. Methodology/Principal Findings: We assessed published studies of the association between these microRNA polymorphisms and cancer risk from eleven studies with 16,771 subjects for miR-196a2 and from ten studies with 15,126 subjects for miR-146a. As for rs11614913, the contrast of homozygote (TT vs CC: OR = 0.92, 95% CI = 0.85–0.99, Pheterogeneity = 0.45), allele (T vs C: OR = 0.96, 95% CI = 0.92–0.99, Pheterogeneity = 0.61) and recessive model (OR = 0.90, 95% CI = 0.84–0.97, Pheterogeneity = 0.50) produced statistically association. Subgroup analysis by ethnicity, statistically significantly decreased cancer risks were found among Asians for allele contrast (OR = 0.95, 95% CI = 0.90–0.99, Pheterogeneity = 0.74) and the recessive genetic model (OR = 0.90, 95% CI = 0.82–0.98, Pheterogeneity = 0.85). According to subgroup analysis by tumor types, the protective effect of C/T polymorphism was only found in breast cancer under allele contrast (T vs C: OR = 0.94, 95% CI = 0.88–0.99, Pheterogeneity = 0.26). For rs2910164, no significant associations were found among overall analysis model with relatively large heterogeneity. Through the stratified analysis, heterogeneity decreased significantly. In the subgroup analyses by cancer types, the C allele of rs2910164 was associated with protection from digestive cancer in allele contrast (C vs G: OR = 0.86, 95% CI = 0.77–0.96, Pheterogeneity = 0.51). Conclusions/Significance: Our meta-analysis suggests that the rs11614913 most likely contributes to decreased susceptibility to cancer, especially in Asians and breast cancer. Besides, the C allele of the rs2910164 might be associated with a protection from digestive cancer.

Suggested Citation

  • Wei Xu & Jijun Xu & Shifeng Liu & Bo Chen & Xueli Wang & Yan Li & Yun Qian & Weihong Zhao & Jianqing Wu, 2011. "Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-7, May.
  • Handle: RePEc:plo:pone00:0020471
    DOI: 10.1371/journal.pone.0020471
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    Cited by:

    1. Jing Guo & Mingjuan Jin & Mingwu Zhang & Kun Chen, 2012. "A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    2. Fang Wang & Guoping Sun & Yanfeng Zou & Lulu Fan & Bing Song, 2012. "Lack of Association of miR-146a rs2910164 Polymorphism with Gastrointestinal Cancers: Evidence from 10206 Subjects," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-7, June.
    3. Kshitij Srivastava & Anvesha Srivastava, 2012. "Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-1, November.
    4. Zhongxia Wang & Yin Cao & Chunping Jiang & Guang Yang & Junhua Wu & Yitao Ding, 2012. "Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
    5. Zhengrong Yuan & Xu Zeng & Dan Yang & Weilu Wang & Zhihua Liu, 2013. "Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.

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