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Socioeconomic and Nutritional Factors Account for the Association of Gastric Cancer with Amerindian Ancestry in a Latin American Admixed Population

Author

Listed:
  • Latife Pereira
  • Roxana Zamudio
  • Giordano Soares-Souza
  • Phabiola Herrera
  • Lilia Cabrera
  • Catherine C Hooper
  • Jaime Cok
  • Juan M Combe
  • Gloria Vargas
  • William A Prado
  • Silvana Schneider
  • Fernanda Kehdy
  • Maira R Rodrigues
  • Stephen J Chanock
  • Douglas E Berg
  • Robert H Gilman
  • Eduardo Tarazona-Santos

Abstract

Gastric cancer is one of the most lethal types of cancer and its incidence varies worldwide, with the Andean region of South America showing high incidence rates. We evaluated the genetic structure of the population from Lima (Peru) and performed a case-control genetic association study to test the contribution of African, European, or Native American ancestry to risk for gastric cancer, controlling for the effect of non-genetic factors. A wide set of socioeconomic, dietary, and clinic information was collected for each participant in the study and ancestry was estimated based on 103 ancestry informative markers. Although the urban population from Lima is usually considered as mestizo (i.e., admixed from Africans, Europeans, and Native Americans), we observed a high fraction of Native American ancestry (78.4% for the cases and 74.6% for the controls) and a very low African ancestry (

Suggested Citation

  • Latife Pereira & Roxana Zamudio & Giordano Soares-Souza & Phabiola Herrera & Lilia Cabrera & Catherine C Hooper & Jaime Cok & Juan M Combe & Gloria Vargas & William A Prado & Silvana Schneider & Ferna, 2012. "Socioeconomic and Nutritional Factors Account for the Association of Gastric Cancer with Amerindian Ancestry in a Latin American Admixed Population," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0041200
    DOI: 10.1371/journal.pone.0041200
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    References listed on IDEAS

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    1. Carlos D. Bustamante & Francisco M. De La Vega & Esteban G. Burchard, 2011. "Genomics for the world," Nature, Nature, vol. 475(7355), pages 163-165, July.
    2. Desmond D Campbell & Maria V Parra & Constanza Duque & Natalia Gallego & Liliana Franco & Arti Tandon & Tábita Hünemeier & Cátira Bortolini & Alberto Villegas & Gabriel Bedoya & Mark I McCarthy & Alke, 2012. "Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
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    Cited by:

    1. Chin-Chia Wu & Ta-Wen Hsu & Chun-Ming Chang & Chia-Hui Yu & Yuh-Feng Wang & Ching-Chih Lee, 2014. "The Effect of Individual and Neighborhood Socioeconomic Status on Gastric Cancer Survival," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-6, February.

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