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Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

Author

Listed:
  • Esteban J Parra
  • Andrew Mazurek
  • Christopher R Gignoux
  • Alexandra Sockell
  • Michael Agostino
  • Andrew P Morris
  • Lauren E Petty
  • Craig L Hanis
  • Nancy J Cox
  • Adan Valladares-Salgado
  • Jennifer E Below
  • Miguel Cruz

Abstract

We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30–40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.

Suggested Citation

  • Esteban J Parra & Andrew Mazurek & Christopher R Gignoux & Alexandra Sockell & Michael Agostino & Andrew P Morris & Lauren E Petty & Craig L Hanis & Nancy J Cox & Adan Valladares-Salgado & Jennifer E , 2017. "Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0172880
    DOI: 10.1371/journal.pone.0172880
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    References listed on IDEAS

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    2. Carlos D. Bustamante & Francisco M. De La Vega & Esteban G. Burchard, 2011. "Genomics for the world," Nature, Nature, vol. 475(7355), pages 163-165, July.
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