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The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis

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  • Qiman Sun
  • Kang Song
  • Xizhong Shen
  • Yu Cai

Abstract

Background: KCNQ1 (potassium voltage-gated channel KQT-like sub-family, member 1) encodes a pore-forming subunit of a voltage-gated K+ channel (KvLQT1) that plays a key role for the repolarization of the cardiac action potential as well as water and salt transport in epithelial tissues. Recently, genome-wide association studies have identified KCNQ1 as a type 2 diabetes (T2D) susceptibility gene in populations of Asian descent. After that, a number of studies reported that the rs2237892 and rs2237895 polymorphism in KCNQ1 has been implicated in T2D risk. However, studies on the association between these polymorphism and T2D remain conflicting. To investigate this inconsistency, we performed this meta-analysis. Methods: Databases including Pubmed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression. Results: A total of 25 articles involving 70,577 T2D cases and 99,068 controls were included. Overall, the summary odds ratio of C allele for T2D was 1.32 (95% CI 1.26–1.38; P

Suggested Citation

  • Qiman Sun & Kang Song & Xizhong Shen & Yu Cai, 2012. "The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0048578
    DOI: 10.1371/journal.pone.0048578
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    1. Desmond D Campbell & Maria V Parra & Constanza Duque & Natalia Gallego & Liliana Franco & Arti Tandon & Tábita Hünemeier & Cátira Bortolini & Alberto Villegas & Gabriel Bedoya & Mark I McCarthy & Alke, 2012. "Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
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    Cited by:

    1. Deng Ao & Hai-jun Wang & Li-fang Wang & Jie-yun Song & Hui-xia Yang & Yan Wang, 2015. "The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.

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