IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0038669.html
   My bibliography  Save this article

Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children

Author

Listed:
  • Meghan B Azad
  • Yuri Lissitsyn
  • Gregory E Miller
  • Allan B Becker
  • Kent T HayGlass
  • Anita L Kozyrskyj

Abstract

Objectives: Lower socioeconomic status (SES) is consistently associated with poor health, yet little is known about the biological mechanisms underlying this inequality. In children, we examined the impact of early-life SES trajectories on the intensity of global innate immune activation, recognizing that excessive activation can be a precursor to inflammation and chronic disease. Methods: Stimulated interleukin-6 production, a measure of immune responsiveness, was analyzed ex vivo for 267 Canadian schoolchildren from a 1995 birth cohort in Manitoba, Canada. Childhood SES trajectories were determined from parent-reported housing data using a longitudinal latent-class modeling technique. Multivariate regression was conducted with adjustment for potential confounders. Results: SES was inversely associated with innate immune responsiveness (p = 0.003), with persistently low-SES children exhibiting responses more than twice as intense as their high-SES counterparts. Despite initially lower SES, responses from children experiencing increasing SES trajectories throughout childhood were indistinguishable from high-SES children. Low-SES effects were strongest among overweight children (p

Suggested Citation

  • Meghan B Azad & Yuri Lissitsyn & Gregory E Miller & Allan B Becker & Kent T HayGlass & Anita L Kozyrskyj, 2012. "Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0038669
    DOI: 10.1371/journal.pone.0038669
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038669
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038669&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0038669?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Loucks, Eric B. & Pilote, Louise & Lynch, John W. & Richard, Hugues & Almeida, Nisha D. & Benjamin, Emelia J. & Murabito, Joanne M., 2010. "Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study," Social Science & Medicine, Elsevier, vol. 71(1), pages 187-195, July.
    2. Kozyrskyj, A.L. & Kendall, G.E. & Jacoby, P. & Sly, P.D. & Zubrick, S.R., 2010. "Association between socioeconomic status and the development of asthma: Analyses of income trajectories," American Journal of Public Health, American Public Health Association, vol. 100(3), pages 540-546.
    3. Johnson, R.C. & Schoeni, R.F., 2011. "Early-life origins of adult disease: National longitudinal population-based study of the United States," American Journal of Public Health, American Public Health Association, vol. 101(12), pages 2317-2324.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Laura Corlin & Mark Woodin & Danny Newhide & Erika Brown & Sarah Valentina Diaz & Amy Chi & Doug Brugge, 2013. "Asthma Associations in Children Attending a Museum of Science," IJERPH, MDPI, vol. 10(9), pages 1-15, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hudson, Darrell L. & Puterman, Eli & Bibbins-Domingo, Kirsten & Matthews, Karen A. & Adler, Nancy E., 2013. "Race, life course socioeconomic position, racial discrimination, depressive symptoms and self-rated health," Social Science & Medicine, Elsevier, vol. 97(C), pages 7-14.
    2. Tyler P. Pittman & Candace I. J. Nykiforuk & Javier Mignone & Piush J. Mandhane & Allan B. Becker & Anita L. Kozyrskyj, 2012. "The Association Between Community Stressors and Asthma Prevalence of School Children in Winnipeg, Canada," IJERPH, MDPI, vol. 9(2), pages 1-17, February.
    3. Gruenewald, Tara L. & Karlamangla, Arun S. & Hu, Perry & Stein-Merkin, Sharon & Crandall, Carolyn & Koretz, Brandon & Seeman, Teresa E., 2012. "History of socioeconomic disadvantage and allostatic load in later life," Social Science & Medicine, Elsevier, vol. 74(1), pages 75-83.
    4. Noghanibehambari, Hamid & Engelman, Michal, 2022. "Social insurance programs and later-life mortality: Evidence from new deal relief spending," Journal of Health Economics, Elsevier, vol. 86(C).
    5. Kim, Dong Ha & Um, Myung-Yong, 2018. "The relationships among family income, parental depression, and adolescent aggression in South Korea: A latent growth mediation model," Children and Youth Services Review, Elsevier, vol. 84(C), pages 168-175.
    6. Alcántara, Carmela & Chen, Chih-Nan & Alegría, Margarita, 2014. "Do post-migration perceptions of social mobility matter for Latino immigrant health?," Social Science & Medicine, Elsevier, vol. 101(C), pages 94-106.
    7. Brady, David & Guerra, Christian & Kohler, Ulrich & Link, Bruce, 2022. "The Long Arm of Prospective Childhood Income for Mature Adult Health in the United States," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 63(4), pages 543-559.
    8. Martin Dumav, 2013. "Health Insurance over the Life Cycle with Adverse Selection," 2013 Meeting Papers 1138, Society for Economic Dynamics.
    9. Fabrizio Bernardi & Risto Conte Keivabu, 2023. "Poor air at school and educational inequalities by family socioeconomic status," MPIDR Working Papers WP-2023-014, Max Planck Institute for Demographic Research, Rostock, Germany.
    10. Adam Thomas & Quentin Karpilow & Kate Welti & Jennifer Manlove & Elizabeth Cook, 2017. "A Microsimulation Model of Fertility, Childbearing, and Child Well-Being," International Journal of Microsimulation, International Microsimulation Association, vol. 10(2), pages 3-58.
    11. Korous, Kevin M. & Surachman, Agus & Rogers, Charles R. & Cuevas, Adolfo G., 2023. "Parental education and epigenetic aging in middle-aged and older adults in the United States: A life course perspective," Social Science & Medicine, Elsevier, vol. 333(C).
    12. Laura Rodríguez, 2022. "Violence and newborn health: Estimates for Colombia," Health Economics, John Wiley & Sons, Ltd., vol. 31(1), pages 112-136, January.
    13. Douglas A. Wolf, 2018. "Uses of Panel Study of Income Dynamics Data in Research on Aging," The ANNALS of the American Academy of Political and Social Science, , vol. 680(1), pages 193-212, November.
    14. Ajay Mahal & Lainie Sutton, 2014. "Economic prosperity and non-communicable disease: understanding the linkages," Chapters, in: Raghbendra Jha & Raghav Gaiha & Anil B. Deolalikar (ed.), Handbook on Food, chapter 12, pages 278-324, Edward Elgar Publishing.
    15. Catalina Torres & Arianna Caporali & Gilles Pison, 2023. "The Human Multiple Births Database (HMBD)," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 48(4), pages 89-106.
    16. Erfanian, Elham & Collins, Alan R., 2020. "Air Quality and Asthma Hospitalization Rates: Evidence of PM2.5 Concentrations in Pennsylvania Counties," Journal of Regional Analysis and Policy, Mid-Continent Regional Science Association, vol. 50(1), January.
    17. Camelo, Lidyane V. & Giatti, Luana & Chor, Dóra & Griep, Rosane Härter & Benseñor, Isabela M. & Santos, Itamar S. & Kawachi, Ichiro & Barreto, Sandhi Maria, 2015. "Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)," Social Science & Medicine, Elsevier, vol. 141(C), pages 91-99.
    18. Hector Cebolla-Boado & Leire Salazar, 2016. "Differences in perinatal health between immigrant and native-origin children: Evidence from differentials in birth weight in Spain," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 35(7), pages 167-200.
    19. Berg, Mark T. & Simons, Ronald L. & Barr, Ashley & Beach, Steven R.H. & Philibert, Robert A., 2017. "Childhood/Adolescent stressors and allostatic load in adulthood: Support for a calibration model," Social Science & Medicine, Elsevier, vol. 193(C), pages 130-139.
    20. Rita C. Ribeiro-Silva & Deborah C. Malta & Laura C. Rodrigues & Dandara O. Ramos & Rosemeire L. Fiaccone & Daiane B. Machado & Maurício L. Barreto, 2018. "Social, Environmental and Behavioral Determinants of Asthma Symptoms in Brazilian Middle School Students—A National School Health Survey (Pense 2012)," IJERPH, MDPI, vol. 15(12), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0038669. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.