IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0032176.html
   My bibliography  Save this article

Alcohol Consumption, Genetic Variants in Alcohol Deydrogenases, and Risk of Cardiovascular Diseases: A Prospective Study and Meta-Analysis

Author

Listed:
  • Dagmar Drogan
  • Abigail J Sheldrick
  • Madlen Schütze
  • Sven Knüppel
  • Frank Andersohn
  • Romina di Giuseppe
  • Bianca Herrmann
  • Stefan N Willich
  • Edeltraut Garbe
  • Manuela M Bergmann
  • Heiner Boeing
  • Cornelia Weikert

Abstract

Objective: First, to investigate and compare associations between alcohol consumption and variants in alcohol dehydrogenase (ADH) genes with incidence of cardiovascular diseases (CVD) in a large German cohort. Second, to quantitatively summarize available evidence of prospective studies on polymorphisms in ADH1B and ADH1C and CVD-risk. Methods: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort including a randomly drawn subcohort (n = 2175) and incident cases of myocardial infarction (MI; n = 230) or stroke (n = 208). Mean follow-up time was 8.2±2.2 years. The association between alcohol consumption, ADH1B or ADH1C genotypes, and CVD-risk was assessed using Cox proportional hazards regression. Additionally, we report results on associations of variants in ADH1B and ADH1C with ischemic heart disease and stroke in the context of a meta-analysis of previously published prospective studies published up to November 2011. Results: Compared to individuals who drank >0 to 6 g alcohol/d, we observed a reduced risk of MI among females consuming >12 g alcohol/d (HR = 0.31; 95% CI: 0.10–0.97) and among males consuming >24 to 60 g/d (HR = 0.57; 95% CI: 0.33–0.98) or >60 g alcohol/d (HR = 0.30; 95% CI: 0.12–0.78). Stroke risk was not significantly related to alcohol consumption >6 g/d, but we observed an increased risk of stroke in men reporting no alcohol consumption. Individuals with the slow-coding ADH1B*1/1 genotype reported higher median alcohol consumption. Yet, polymorphisms in ADH1B or ADH1C were not significantly associated with risk of CVD in our data and after pooling results of eligible prospective studies [ADH1B*1/1: RR = 1.35 (95% CI: 0.98–1.88; p for heterogeneity: 0.364); ADH1C*2/2: RR = 1.07 (95% CI: 0.90–1.27; p for heterogeneity: 0.098)]. Conclusion: The well described association between alcohol consumption and CVD-risk is not reflected by ADH polymorphisms, which modify the rate of ethanol oxidation.

Suggested Citation

  • Dagmar Drogan & Abigail J Sheldrick & Madlen Schütze & Sven Knüppel & Frank Andersohn & Romina di Giuseppe & Bianca Herrmann & Stefan N Willich & Edeltraut Garbe & Manuela M Bergmann & Heiner Boeing &, 2012. "Alcohol Consumption, Genetic Variants in Alcohol Deydrogenases, and Risk of Cardiovascular Diseases: A Prospective Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
  • Handle: RePEc:plo:pone00:0032176
    DOI: 10.1371/journal.pone.0032176
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032176
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032176&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0032176?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Guohong Zhang & Ruiqin Mai & Bo Huang, 2010. "ADH1B Arg47His Polymorphism Is Associated with Esophageal Cancer Risk in High-Incidence Asian Population: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 5(10), pages 1-5, October.
    2. Lina Chen & George Davey Smith & Roger M Harbord & Sarah J Lewis, 2008. "Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach," PLOS Medicine, Public Library of Science, vol. 5(3), pages 1-11, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Golder, Su & McCambridge, Jim, 2021. "Alcohol, cardiovascular disease and industry funding: A co-authorship network analysis of systematic reviews," Social Science & Medicine, Elsevier, vol. 289(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stephanie Hinke Kessler Scholder & George L. Wehby & Sarah Lewis & Luisa Zuccolo, 2014. "Alcohol Exposure In Utero and Child Academic Achievement," Economic Journal, Royal Economic Society, vol. 0(576), pages 634-667, May.
    2. von Hinke Kessler Scholder S, 2009. "Genetic Markers as Instrumental Variables: An Application to Child Fat Mass and Academic Achievement," Health, Econometrics and Data Group (HEDG) Working Papers 09/25, HEDG, c/o Department of Economics, University of York.
    3. Mengying Wang & Wenyong Li & Ren Zhou & Siyue Wang & Hongchen Zheng & Jin Jiang & Shengfeng Wang & Canqing Yu & Wenjing Gao & Jun Lv & Tao Wu & Weihua Cao & Yonghua Hu & Liming Li & John S. Ji, 2020. "The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
    4. Dixon, Padraig & Hollingworth, William & Harrison, Sean & Davies, Neil M. & Davey Smith, George, 2020. "Mendelian Randomization analysis of the causal effect of adiposity on hospital costs," Journal of Health Economics, Elsevier, vol. 70(C).
    5. Yawen Wang & Yuntong Yao & Yun Chen & Jie Zhou & Yanli Wu & Chaowei Fu & Na Wang & Tao Liu & Kelin Xu, 2022. "Association between Drinking Patterns and Incident Hypertension in Southwest China," IJERPH, MDPI, vol. 19(7), pages 1-20, March.
    6. Yinyin Wu & Juntao Ni & Xiao Cai & Fuzhi Lian & Haiyan Ma & Liangwen Xu & Lei Yang, 2017. "Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-16, May.
    7. Chenhao Yu & Huigang Liang & Zhiruo Zhang, 2022. "Does Health Insurance Reduce the Alcohol Consumption? Evidence from China Health and Nutrition Survey," Sustainability, MDPI, vol. 14(9), pages 1-10, May.
    8. Oksoo Kim & Bo Hye Kim & Hae Ok Jeon, 2012. "Risk factors related to hazardous alcohol consumption among Korean men with hypertension," Nursing & Health Sciences, John Wiley & Sons, vol. 14(2), pages 204-212, June.
    9. Stephanie von Hinke Kessler Scholder & George Davey Smith & Debbie A. Lawlor & Carol Propper & Frank Windmeijer, 2011. "Mendelian randomization: the use of genes in instrumental variable analyses," Health Economics, John Wiley & Sons, Ltd., vol. 20(8), pages 893-896, August.
    10. Yongho Jee & Susan Park & Eunu Yuk & Sung-il Cho, 2021. "Alcohol Consumption and Cigarette Smoking among Young Adults: An Instrumental Variable Analysis Using Alcohol Flushing," IJERPH, MDPI, vol. 18(21), pages 1-9, October.
    11. Golder, Su & McCambridge, Jim, 2021. "Alcohol, cardiovascular disease and industry funding: A co-authorship network analysis of systematic reviews," Social Science & Medicine, Elsevier, vol. 289(C).
    12. Shiu Lun Au Yeung & Chaoqiang Jiang & Kar Keung Cheng & Benjamin J Cowling & Bin Liu & Weisen Zhang & Tai Hing Lam & Gabriel M Leung & C Mary Schooling, 2013. "Moderate Alcohol Use and Cardiovascular Disease from Mendelian Randomization," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0032176. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.