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Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

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  • Yinyin Wu
  • Juntao Ni
  • Xiao Cai
  • Fuzhi Lian
  • Haiyan Ma
  • Liangwen Xu
  • Lei Yang

Abstract

Background and objective: Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. Methods: One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Results: Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P

Suggested Citation

  • Yinyin Wu & Juntao Ni & Xiao Cai & Fuzhi Lian & Haiyan Ma & Liangwen Xu & Lei Yang, 2017. "Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-16, May.
  • Handle: RePEc:plo:pone00:0177023
    DOI: 10.1371/journal.pone.0177023
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