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A Dopaminergic Gene Cluster in the Prefrontal Cortex Predicts Performance Indicative of General Intelligence in Genetically Heterogeneous Mice

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  • Stefan Kolata
  • Kenneth Light
  • Christopher D Wass
  • Danielle Colas-Zelin
  • Debasri Roy
  • Louis D Matzel

Abstract

Background: Genetically heterogeneous mice express a trait that is qualitatively and psychometrically analogous to general intelligence in humans, and as in humans, this trait co-varies with the processing efficacy of working memory (including its dependence on selective attention). Dopamine signaling in the prefrontal cortex (PFC) has been established to play a critical role in animals' performance in both working memory and selective attention tasks. Owing to this role of the PFC in the regulation of working memory, here we compared PFC gene expression profiles of 60 genetically diverse CD-1 mice that exhibited a wide range of general learning abilities (i.e., aggregate performance across five diverse learning tasks). Methodology/Principal Findings: Animals' general cognitive abilities were first determined based on their aggregate performance across a battery of five diverse learning tasks. With a procedure designed to minimize false positive identifications, analysis of gene expression microarrays (comprised of ≈25,000 genes) identified a small number (

Suggested Citation

  • Stefan Kolata & Kenneth Light & Christopher D Wass & Danielle Colas-Zelin & Debasri Roy & Louis D Matzel, 2010. "A Dopaminergic Gene Cluster in the Prefrontal Cortex Predicts Performance Indicative of General Intelligence in Genetically Heterogeneous Mice," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0014036
    DOI: 10.1371/journal.pone.0014036
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    References listed on IDEAS

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    1. Jonathan D. Cohen & William M. Perlstein & Todd S. Braver & Leigh E. Nystrom & Douglas C. Noll & John Jonides & Edward E. Smith, 1997. "Temporal dynamics of brain activation during a working memory task," Nature, Nature, vol. 386(6625), pages 604-608, April.
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    1. Matzel, Louis D. & Bendrath, Sophie & Herzfeld, Margalit & Crawford, Dylan W. & Sauce, Bruno, 2019. "Mouse twins separated when young: A history of exploration doubles the heritability of boldness and differentially affects the heritability of measures of learning," Intelligence, Elsevier, vol. 74(C), pages 34-42.
    2. Woodley of Menie, Michael A. & Peñaherrera-Aguirre, Mateo & Sarraf, Matthew A., 2022. "Signs of a Flynn effect in rodents? Secular differentiation of the manifold of general cognitive ability in laboratory mice (Mus musculus) and Norwegian rats (Rattus norvegicus) over a century—Results," Intelligence, Elsevier, vol. 95(C).

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