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Dynamical footprints enable detection of disease emergence

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  • Tobias S Brett
  • Pejman Rohani

Abstract

Developing methods for anticipating the emergence or reemergence of infectious diseases is both important and timely; however, traditional model-based approaches are stymied by uncertainty surrounding the underlying drivers. Here, we demonstrate an operational, mechanism-agnostic detection algorithm for disease (re-)emergence based on early warning signals (EWSs) derived from the theory of critical slowing down. Specifically, we used computer simulations to train a supervised learning algorithm to detect the dynamical footprints of (re-)emergence present in epidemiological data. Our algorithm was then challenged to forecast the slowly manifesting, spatially replicated reemergence of mumps in England in the mid-2000s and pertussis post-1980 in the United States. Our method successfully anticipated mumps reemergence 4 years in advance, during which time mitigation efforts could have been implemented. From 1980 onwards, our model identified resurgent states with increasing accuracy, leading to reliable classification starting in 1992. Additionally, we successfully applied the detection algorithm to 2 vector-transmitted case studies, namely, outbreaks of dengue serotypes in Puerto Rico and a rapidly unfolding outbreak of plague in 2017 in Madagascar. Taken together, these findings illustrate the power of theoretically informed machine learning techniques to develop early warning systems for the (re-)emergence of infectious diseases.This study develops an operational algorithm for the detection of the (re-)emergence of infectious disease. The authors illustrate its utility by successfully applying it to four (re-)emerging threats—mumps, pertussis, dengue and plague, providing early warning that could enable intervention measures.

Suggested Citation

  • Tobias S Brett & Pejman Rohani, 2020. "Dynamical footprints enable detection of disease emergence," PLOS Biology, Public Library of Science, vol. 18(5), pages 1-20, May.
    • Handle: RePEc:plo:pbio00:3000697
    DOI: 10.1371/journal.pbio.3000697
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    References listed on IDEAS

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    1. Wei, Wei & Xu, Wei & Song, Yi & Liu, Jiankang, 2021. "Bifurcation and basin stability of an SIR epidemic model with limited medical resources and switching noise," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).

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