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Modelling of covariance structures in generalised estimating equations for longitudinal data

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  • Huajun Ye
  • Jianxin Pan

Abstract

When used for modelling longitudinal data generalised estimating equations specify a working structure for the within-subject covariance matrices, aiming to produce efficient parameter estimators. However, misspecification of the working covariance structure may lead to a large loss of efficiency of the estimators of the mean parameters. In this paper we propose an approach for joint modelling of the mean and covariance structures of longitudinal data within the framework of generalised estimating equations. The resulting estimators for the mean and covariance parameters are shown to be consistent and asymptotically Normally distributed. Real data analysis and simulation studies show that the proposed approach yields e?cient estimators for both the mean and covariance parameters. Copyright 2006, Oxford University Press.

Suggested Citation

  • Huajun Ye & Jianxin Pan, 2006. "Modelling of covariance structures in generalised estimating equations for longitudinal data," Biometrika, Biometrika Trust, vol. 93(4), pages 927-941, December.
    • Handle: RePEc:oup:biomet:v:93:y:2006:i:4:p:927-941
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    File URL: http://hdl.handle.net/10.1093/biomet/93.4.927
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    Cited by:

    1. Xueying Zheng & Wing Fung & Zhongyi Zhu, 2013. "Robust estimation in joint mean–covariance regression model for longitudinal data," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 65(4), pages 617-638, August.
    2. Chaohui Guo & Hu Yang & Jing Lv, 2018. "Two step estimations for a single-index varying-coefficient model with longitudinal data," Statistical Papers, Springer, vol. 59(3), pages 957-983, September.
    3. Lv, Jing & Guo, Chaohui & Yang, Hu & Li, Yalian, 2017. "A moving average Cholesky factor model in covariance modeling for composite quantile regression with longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 112(C), pages 129-144.
    4. Guney, Yesim & Arslan, Olcay & Yavuz, Fulya Gokalp, 2022. "Robust estimation in multivariate heteroscedastic regression models with autoregressive covariance structures using EM algorithm," Journal of Multivariate Analysis, Elsevier, vol. 191(C).
    5. Jing Lv & Chaohui Guo, 2017. "Efficient parameter estimation via modified Cholesky decomposition for quantile regression with longitudinal data," Computational Statistics, Springer, vol. 32(3), pages 947-975, September.
    6. Yu, Jing & Nummi, Tapio & Pan, Jianxin, 2022. "Mixture regression for longitudinal data based on joint mean–covariance model," Journal of Multivariate Analysis, Elsevier, vol. 190(C).
    7. Lin, Lijing & Higham, Nicholas J. & Pan, Jianxin, 2014. "Covariance structure regularization via entropy loss function," Computational Statistics & Data Analysis, Elsevier, vol. 72(C), pages 315-327.
    8. Li, Daoji & Pan, Jianxin, 2013. "Empirical likelihood for generalized linear models with longitudinal data," Journal of Multivariate Analysis, Elsevier, vol. 114(C), pages 63-73.
    9. Dengke Xu & Zhongzhan Zhang & Liucang Wu, 2014. "Bayesian analysis of joint mean and covariance models for longitudinal data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(11), pages 2504-2514, November.
    10. Feng, Sanying & Lian, Heng & Xue, Liugen, 2016. "A new nested Cholesky decomposition and estimation for the covariance matrix of bivariate longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 102(C), pages 98-109.
    11. Jing Lv & Chaohui Guo, 2019. "Quantile estimations via modified Cholesky decomposition for longitudinal single-index models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 71(5), pages 1163-1199, October.
    12. Xu, Lin & Xiang, Sijia & Yao, Weixin, 2019. "Robust maximum Lq-likelihood estimation of joint mean–covariance models for longitudinal data," Journal of Multivariate Analysis, Elsevier, vol. 171(C), pages 397-411.
    13. Chen, Ziqi & Shi, Ning-Zhong & Gao, Wei & Tang, Man-Lai, 2011. "Efficient semiparametric estimation via Cholesky decomposition for longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3344-3354, December.
    14. Zhang, Qiang & Ip, Edward H. & Pan, Junhao & Plemmons, Robert, 2017. "Individual-specific, sparse inverse covariance estimation in generalized estimating equations," Statistics & Probability Letters, Elsevier, vol. 122(C), pages 96-103.
    15. Huang, Youjun & Pan, Jianxin, 2021. "Joint generalized estimating equations for longitudinal binary data," Computational Statistics & Data Analysis, Elsevier, vol. 155(C).
    16. Jing Lv & Chaohui Guo & Jibo Wu, 2019. "Smoothed empirical likelihood inference via the modified Cholesky decomposition for quantile varying coefficient models with longitudinal data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(3), pages 999-1032, September.
    17. Christopher A. German & Janet S. Sinsheimer & Jin Zhou & Hua Zhou, 2022. "WiSER: Robust and scalable estimation and inference of within‐subject variances from intensive longitudinal data," Biometrics, The International Biometric Society, vol. 78(4), pages 1313-1327, December.
    18. Hongmei Lin & Wenchao Xu & Riquan Zhang & Jianhong Shi & Yuedong Wang, 2017. "Multiple-index varying-coefficient models for longitudinal data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 44(11), pages 1960-1978, August.
    19. Luo, Renwen & Pan, Jianxin, 2022. "Conditional generalized estimating equations of mean-variance-correlation for clustered data," Computational Statistics & Data Analysis, Elsevier, vol. 168(C).
    20. Peng, Cheng & Yang, Yihe & Zhou, Jie & Pan, Jianxin, 2022. "Latent Gaussian copula models for longitudinal binary data," Journal of Multivariate Analysis, Elsevier, vol. 189(C).
    21. Ziqi Chen & Man†Lai Tang & Wei Gao, 2018. "A profile likelihood approach for longitudinal data analysis," Biometrics, The International Biometric Society, vol. 74(1), pages 220-228, March.
    22. Lu, Fei & Xue, Liugen & Cai, Xiong, 2020. "GEE analysis in joint mean-covariance model for longitudinal data," Statistics & Probability Letters, Elsevier, vol. 160(C).
    23. Yixin Chen & Weixin Yao, 2017. "Unified Inference for Sparse and Dense Longitudinal Data in Time-varying Coefficient Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 44(1), pages 268-284, March.

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