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Effects of PM Exposure on the Methylation of Clock Genes in A Population of Subjects with Overweight or Obesity

Author

Listed:
  • Paola Monti

    (Department of Preventive Medicine, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Simona Iodice

    (EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Letizia Tarantini

    (EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Francesca Sacchi

    (EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Luca Ferrari

    (EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Massimiliano Ruscica

    (Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy)

  • Massimiliano Buoli

    (Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy
    Department of Neurosciences and Mental Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Luisella Vigna

    (Department of Preventive Medicine, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Center of Obesity and Work EASO Collaborating Centers for Obesity Management, 20122 Milan, Italy)

  • Angela Cecilia Pesatori

    (Department of Preventive Medicine, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Valentina Bollati

    (EPIGET—Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

Abstract

The expression of clock genes, regulating the synchronization of metabolic and behavioral processes with environmental light/dark cycles, is regulated by methylation and might be influenced by short-term exposure to airborne particulate matter (PM), especially in individuals that are hypersensitive to proinflammatory cues. The present study aimed to evaluate the effects of PM 2.5 and PM 10 on the methylation profile of the clock genes ARNTL , CLOCK , CRY1 , CRY2 , PER1 , PER2 , and PER3 in a population of 200 women with obesity. A significant association between PM 10 exposure and the methylation of clock genes was found, namely, this was negative for PER2 gene and positive for the CLOCK , CRY1 , CRY2 , and PER3 genes. PM 2.5 was negatively associated with methylation of PER2 gene and positively with methylation of CRY2 gene. Evidence was observed for effect modification from body mass index (BMI) regarding the PER1 gene: as PM 2.5/10 increases, DNA methylation increases significantly for relatively low BMI values (BMI = 25), while it decreases in participants with severe obesity (BMI = 51). PM may therefore alter the epigenetic regulation of clock genes, possibly affecting circadian rhythms. Future studies are needed to clarify how alterations in clock gene methylation are predictive of disease development and how obesity can modulate the adverse health effects of PM.

Suggested Citation

  • Paola Monti & Simona Iodice & Letizia Tarantini & Francesca Sacchi & Luca Ferrari & Massimiliano Ruscica & Massimiliano Buoli & Luisella Vigna & Angela Cecilia Pesatori & Valentina Bollati, 2021. "Effects of PM Exposure on the Methylation of Clock Genes in A Population of Subjects with Overweight or Obesity," IJERPH, MDPI, vol. 18(3), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1122-:d:488115
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    References listed on IDEAS

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    1. Pierre Brochu & Michèle Bouchard & Sami Haddad, 2014. "Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly," Risk Analysis, John Wiley & Sons, vol. 34(3), pages 567-582, March.
    2. Pengcheng Song & Zhigang Li & Xiaoqian Li & Lixin Yang & Lulu Zhang & Nannan Li & Chen Guo & Shuyu Lu & Yongjie Wei, 2017. "Transcriptome Profiling of the Lungs Reveals Molecular Clock Genes Expression Changes after Chronic Exposure to Ambient Air Particles," IJERPH, MDPI, vol. 14(1), pages 1-10, January.
    3. Simone Wahl & Alexander Drong & Benjamin Lehne & Marie Loh & William R. Scott & Sonja Kunze & Pei-Chien Tsai & Janina S. Ried & Weihua Zhang & Youwen Yang & Sili Tan & Giovanni Fiorito & Lude Franke &, 2017. "Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity," Nature, Nature, vol. 541(7635), pages 81-86, January.
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    Cited by:

    1. Michele Carugno & Cristina Maggioni & Vincenzo Ruggiero & Eleonora Crespi & Paola Monti & Luca Ferrari & Angela Cecilia Pesatori, 2021. "Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses," IJERPH, MDPI, vol. 18(20), pages 1-6, October.
    2. Antonello E. Rigamonti & Valentina Bollati & Chiara Favero & Benedetta Albetti & Diana Caroli & Alessandra De Col & Silvano G. Cella & Alessandro Sartorio, 2022. "Changes in DNA Methylation of Clock Genes in Obese Adolescents after a Short-Term Body Weight Reduction Program: A Possible Metabolic and Endocrine Chrono-Resynchronization," IJERPH, MDPI, vol. 19(23), pages 1-19, November.

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