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The emergence of functional microcircuits in visual cortex

Author

Listed:
  • Ho Ko

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Lee Cossell

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Chiara Baragli

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Jan Antolik

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Present address: Unité de Neuroscience Information et Complexité, UPR 3293 CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.)

  • Claudia Clopath

    (Center for Theoretical Neuroscience, Columbia University, 1051 Riverside Drive, Unit 87 Kolb Research Annex, New York, New York 10032, USA)

  • Sonja B. Hofer

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Thomas D. Mrsic-Flogel

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

Abstract

A study of mouse visual cortex relating patterns of excitatory synaptic connectivity to visual response properties of neighbouring neurons shows that, after eye opening, local connectivity reorganizes extensively: more connections form selectively between neurons with similar visual responses and connections are eliminated between visually unresponsive neurons, but the overall connectivity rate does not change.

Suggested Citation

  • Ho Ko & Lee Cossell & Chiara Baragli & Jan Antolik & Claudia Clopath & Sonja B. Hofer & Thomas D. Mrsic-Flogel, 2013. "The emergence of functional microcircuits in visual cortex," Nature, Nature, vol. 496(7443), pages 96-100, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature12015
    DOI: 10.1038/nature12015
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    Citations

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    Cited by:

    1. Dimitri Yatsenko & Krešimir Josić & Alexander S Ecker & Emmanouil Froudarakis & R James Cotton & Andreas S Tolias, 2015. "Improved Estimation and Interpretation of Correlations in Neural Circuits," PLOS Computational Biology, Public Library of Science, vol. 11(3), pages 1-28, March.
    2. Mikael Lundqvist & Scott L. Brincat & Jonas Rose & Melissa R. Warden & Timothy J. Buschman & Earl K. Miller & Pawel Herman, 2023. "Working memory control dynamics follow principles of spatial computing," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Cecilia L Friedrichs-Maeder & Alessandra Griffa & Juliane Schneider & Petra Susan Hüppi & Anita Truttmann & Patric Hagmann, 2017. "Exploring the role of white matter connectivity in cortex maturation," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-18, May.
    4. Gabriel Koch Ocker & Ashok Litwin-Kumar & Brent Doiron, 2015. "Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses," PLOS Computational Biology, Public Library of Science, vol. 11(8), pages 1-40, August.
    5. Chao Chen & Linlin Sun & Avital Adler & Hang Zhou & Licheng Zhang & Lihai Zhang & Junhao Deng & Yang Bai & Jinhui Zhang & Guang Yang & Wen-Biao Gan & Peifu Tang, 2023. "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Sadra Sadeh & Stefan Rotter, 2015. "Orientation Selectivity in Inhibition-Dominated Networks of Spiking Neurons: Effect of Single Neuron Properties and Network Dynamics," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-17, January.
    7. Brian B. Jeon & Thomas Fuchs & Steven M. Chase & Sandra J. Kuhlman, 2022. "Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Suchin S Gururangan & Alexander J Sadovsky & Jason N MacLean, 2014. "Analysis of Graph Invariants in Functional Neocortical Circuitry Reveals Generalized Features Common to Three Areas of Sensory Cortex," PLOS Computational Biology, Public Library of Science, vol. 10(7), pages 1-12, July.
    10. Dominic J. Vita & Fernanda S. Orsi & Nathan G. Stanko & Natalie A. Clark & Alexandre Tiriac, 2024. "Development and organization of the retinal orientation selectivity map," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    11. Pierre Yger & Kenneth D Harris, 2013. "The Convallis Rule for Unsupervised Learning in Cortical Networks," PLOS Computational Biology, Public Library of Science, vol. 9(10), pages 1-16, October.
    12. Disheng Tang & Joel Zylberberg & Xiaoxuan Jia & Hannah Choi, 2024. "Stimulus type shapes the topology of cellular functional networks in mouse visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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