IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v496y2013i7443d10.1038_nature12015.html
   My bibliography  Save this article

The emergence of functional microcircuits in visual cortex

Author

Listed:
  • Ho Ko

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Lee Cossell

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Chiara Baragli

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Jan Antolik

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Present address: Unité de Neuroscience Information et Complexité, UPR 3293 CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.)

  • Claudia Clopath

    (Center for Theoretical Neuroscience, Columbia University, 1051 Riverside Drive, Unit 87 Kolb Research Annex, New York, New York 10032, USA)

  • Sonja B. Hofer

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

  • Thomas D. Mrsic-Flogel

    (Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK)

Abstract

A study of mouse visual cortex relating patterns of excitatory synaptic connectivity to visual response properties of neighbouring neurons shows that, after eye opening, local connectivity reorganizes extensively: more connections form selectively between neurons with similar visual responses and connections are eliminated between visually unresponsive neurons, but the overall connectivity rate does not change.

Suggested Citation

  • Ho Ko & Lee Cossell & Chiara Baragli & Jan Antolik & Claudia Clopath & Sonja B. Hofer & Thomas D. Mrsic-Flogel, 2013. "The emergence of functional microcircuits in visual cortex," Nature, Nature, vol. 496(7443), pages 96-100, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature12015
    DOI: 10.1038/nature12015
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12015
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12015?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mikael Lundqvist & Scott L. Brincat & Jonas Rose & Melissa R. Warden & Timothy J. Buschman & Earl K. Miller & Pawel Herman, 2023. "Working memory control dynamics follow principles of spatial computing," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Cecilia L Friedrichs-Maeder & Alessandra Griffa & Juliane Schneider & Petra Susan Hüppi & Anita Truttmann & Patric Hagmann, 2017. "Exploring the role of white matter connectivity in cortex maturation," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-18, May.
    3. Chao Chen & Linlin Sun & Avital Adler & Hang Zhou & Licheng Zhang & Lihai Zhang & Junhao Deng & Yang Bai & Jinhui Zhang & Guang Yang & Wen-Biao Gan & Peifu Tang, 2023. "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Brian B. Jeon & Thomas Fuchs & Steven M. Chase & Sandra J. Kuhlman, 2022. "Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Suchin S Gururangan & Alexander J Sadovsky & Jason N MacLean, 2014. "Analysis of Graph Invariants in Functional Neocortical Circuitry Reveals Generalized Features Common to Three Areas of Sensory Cortex," PLOS Computational Biology, Public Library of Science, vol. 10(7), pages 1-12, July.
    7. Dominic J. Vita & Fernanda S. Orsi & Nathan G. Stanko & Natalie A. Clark & Alexandre Tiriac, 2024. "Development and organization of the retinal orientation selectivity map," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    8. Disheng Tang & Joel Zylberberg & Xiaoxuan Jia & Hannah Choi, 2024. "Stimulus type shapes the topology of cellular functional networks in mouse visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    9. Dimitri Yatsenko & Krešimir Josić & Alexander S Ecker & Emmanouil Froudarakis & R James Cotton & Andreas S Tolias, 2015. "Improved Estimation and Interpretation of Correlations in Neural Circuits," PLOS Computational Biology, Public Library of Science, vol. 11(3), pages 1-28, March.
    10. Gabriel Koch Ocker & Ashok Litwin-Kumar & Brent Doiron, 2015. "Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses," PLOS Computational Biology, Public Library of Science, vol. 11(8), pages 1-40, August.
    11. Sadra Sadeh & Stefan Rotter, 2015. "Orientation Selectivity in Inhibition-Dominated Networks of Spiking Neurons: Effect of Single Neuron Properties and Network Dynamics," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-17, January.
    12. Pierre Yger & Kenneth D Harris, 2013. "The Convallis Rule for Unsupervised Learning in Cortical Networks," PLOS Computational Biology, Public Library of Science, vol. 9(10), pages 1-16, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature12015. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.