IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v459y2009i7250d10.1038_nature08182.html
   My bibliography  Save this article

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

Author

Listed:
  • Gavin J. D. Smith

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Dhanasekaran Vijaykrishna

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Justin Bahl

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Samantha J. Lycett

    (Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King’s Buildings, Edinburgh EH9 3JT, UK)

  • Michael Worobey

    (University of Arizona, Tucson, Arizona 85705, USA)

  • Oliver G. Pybus

    (University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • Siu Kit Ma

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Chung Lam Cheung

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Jayna Raghwani

    (Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King’s Buildings, Edinburgh EH9 3JT, UK)

  • Samir Bhatt

    (University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • J. S. Malik Peiris

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Yi Guan

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China)

  • Andrew Rambaut

    (Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King’s Buildings, Edinburgh EH9 3JT, UK)

Abstract

H1N1 pandemic virus analysed A phylogenetic analysis of swine-origin H1N1 influenza A virus provides evidence that the virus is a reassortment possessing genes from avian, swine and human origin viruses. The pandemic virus appears to have evolved in way typical of swine flu sequences prior to entering humans, and is derived from several viruses circulating in swine. Initial transmission to humans appears to have occurred several months before recognition of the outbreak. An estimate of the gaps in genetic surveillance points to a period of years between the reassortment of swine lineages and the transfer to humans and the multiple genetic ancestry is inconsistent with an artificial origin for the virus. The gaps in out knowledge revealed by this work highlight the need for the systematic surveillance of influence in swine as a means of identifying potentially pandemic strains before they cross into human populations.

Suggested Citation

  • Gavin J. D. Smith & Dhanasekaran Vijaykrishna & Justin Bahl & Samantha J. Lycett & Michael Worobey & Oliver G. Pybus & Siu Kit Ma & Chung Lam Cheung & Jayna Raghwani & Samir Bhatt & J. S. Malik Peiris, 2009. "Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic," Nature, Nature, vol. 459(7250), pages 1122-1125, June.
  • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08182
    DOI: 10.1038/nature08182
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08182
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature08182?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mario Arturo Ruiz Estrada & Evangelos Koutronas & Donghyun Park & Alam Khan & Muhammad Tahir, 2023. "The impact of COVID-19 on the economic performance of Wuhan, China (2019–2021)," Quality & Quantity: International Journal of Methodology, Springer, vol. 57(1), pages 847-862, February.
    2. Shanshan Chen & Yijun Ran & Hebo Huang & Zhenzhen Wang & Ke-ke Shang, 2022. "Epidemic Dynamics of Two-Pathogen Spreading for Pairwise Models," Mathematics, MDPI, vol. 10(11), pages 1-18, June.
    3. Igor Balaz & Taichi Haruna, 2018. "Evolution Of Influenza A Nucleotide Segments Through The Lens Of Different Complexity Measures," Advances in Complex Systems (ACS), World Scientific Publishing Co. Pte. Ltd., vol. 21(05), pages 1-24, August.
    4. Guo, Zun-Guang & Sun, Gui-Quan & Wang, Zhen & Jin, Zhen & Li, Li & Li, Can, 2020. "Spatial dynamics of an epidemic model with nonlocal infection," Applied Mathematics and Computation, Elsevier, vol. 377(C).
    5. Goulas, Sofoklis & Megalokonomou, Rigissa, 2016. "Swine Flu and The Effect of Compulsory Class Attendance on Academic Performance," MPRA Paper 75395, University Library of Munich, Germany.
    6. Cecilia Solér, 2012. "Conceptualizing Sustainably Produced Food for Promotional Purposes: A Sustainable Marketing Approach," Sustainability, MDPI, vol. 4(3), pages 1-47, March.
    7. Finlay Campbell & Anne Cori & Neil Ferguson & Thibaut Jombart, 2019. "Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data," PLOS Computational Biology, Public Library of Science, vol. 15(3), pages 1-20, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08182. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.