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Adipocytes as regulators of energy balance and glucose homeostasis

Author

Listed:
  • Evan D. Rosen

    (Beth Israel Deaconess Medical Centre)

  • Bruce M. Spiegelman

    (Dana–Farber Cancer Institute)

Abstract

Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity and metabolic diseases such as type 2 diabetes. Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions.

Suggested Citation

  • Evan D. Rosen & Bruce M. Spiegelman, 2006. "Adipocytes as regulators of energy balance and glucose homeostasis," Nature, Nature, vol. 444(7121), pages 847-853, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05483
    DOI: 10.1038/nature05483
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    Cited by:

    1. Ravikanth Nanduri & Takashi Furusawa & Alexei Lobanov & Bing He & Carol Xie & Kimia Dadkhah & Michael C. Kelly & Oksana Gavrilova & Frank J. Gonzalez & Michael Bustin, 2022. "Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Melkaye G Melka & Michal Abrahamowicz & Gabriel T Leonard & Michel Perron & Louis Richer & Suzanne Veillette & Daniel Gaudet & Tomáš Paus & Zdenka Pausova, 2013. "Clustering of the Metabolic Syndrome Components in Adolescence: Role of Visceral Fat," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    3. Stephen J. Gaudino & Ankita Singh & Huakang Huang & Jyothi Padiadpu & Makheni Jean-Pierre & Cody Kempen & Tej Bahadur & Kiyoshi Shiomitsu & Richard Blumberg & Kenneth R. Shroyer & Semir Beyaz & Natali, 2024. "Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. YunSook Jung & Ji-Hye Kim & Ah-Ra Shin & Keun-Bae Song & Atsuo Amano & Youn-Hee Choi, 2023. "Association of Adiposity with Periodontitis and Metabolic Syndrome: From the Third National Health and Nutrition Examination Survey of United States," IJERPH, MDPI, vol. 20(3), pages 1-9, January.
    5. Meiqi Fan & Eun-Kyung Kim & Young-Jin Choi & Yujiao Tang & Sang-Ho Moon, 2019. "The Role of Momordica charantia in Resisting Obesity," IJERPH, MDPI, vol. 16(18), pages 1-17, September.
    6. Cheng Xiao & Elke Albrecht & Dirk Dannenberger & Weibo Kong & Hao Gu & Harald M. Hammon & Steffen Maak, 2024. "Effects of Supplementation with Essential Fatty Acids and Conjugated Linoleic Acids on Muscle Structure and Fat Deposition in Lactating Holstein Cows," Agriculture, MDPI, vol. 14(10), pages 1-18, September.
    7. Gregory Alexander Raciti & Francesca Fiory & Michele Campitelli & Antonella Desiderio & Rosa Spinelli & Michele Longo & Cecilia Nigro & Giacomo Pepe & Eduardo Sommella & Pietro Campiglia & Pietro Form, 2018. "Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-20, March.
    8. Ewa Bielczyk-Maczynska & Meng Zhao & Peter-James H. Zushin & Theresia M. Schnurr & Hyun-Jung Kim & Jiehan Li & Pratima Nallagatla & Panjamaporn Sangwung & Chong Y. Park & Cameron Cornn & Andreas Stahl, 2022. "G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. Motohiro Sekiya & Kenta Kainoh & Takehito Sugasawa & Ryunosuke Yoshino & Takatsugu Hirokawa & Hiroaki Tokiwa & Shogo Nakano & Satoru Nagatoishi & Kouhei Tsumoto & Yoshinori Takeuchi & Takafumi Miyamot, 2021. "The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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