IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0082368.html
   My bibliography  Save this article

Clustering of the Metabolic Syndrome Components in Adolescence: Role of Visceral Fat

Author

Listed:
  • Melkaye G Melka
  • Michal Abrahamowicz
  • Gabriel T Leonard
  • Michel Perron
  • Louis Richer
  • Suzanne Veillette
  • Daniel Gaudet
  • Tomáš Paus
  • Zdenka Pausova

Abstract

Visceral fat (VF) promotes the development of metabolic syndrome (MetS), which emerges as early as in adolescence. The clustering of MetS components suggests shared etiologies, but these are largely unknown and may vary between males and females. Here, we investigated the latent structure of pre-clinical MetS in a community-based sample of 286 male and 312 female adolescents, assessing their abdominal adiposity (VF) directly with magnetic resonance imaging. Principal component analysis of the five MetS-defining variables (VF, blood pressure [BP], fasting serum triglycerides, HDL-cholesterol and glucose) identified two independent components in both males and females. The first component was sex-similar; it explained >30% of variance and was loaded by all but BP variables. The second component explained >20% of variance; it was loaded by BP similarly in both sexes but additional loading by metabolic variables was sex-specific. This sex-specificity was not detected in analyses that used waist circumference instead of VF. In adolescence, MetS-defining variables cluster into at least two sub-syndromes: (1) sex-similar metabolic abnormalities of obesity-induced insulin resistance and (2) sex-specific metabolic abnormalities associated with BP elevation. These results suggest that the etiology of MetS may involve more than one pathway and that some of the pathways may differ between males and females. Further, the sex-specific metabolic abnormalities associated with BP elevation suggest the need for sex-specific prevention and treatment strategies of MetS.

Suggested Citation

  • Melkaye G Melka & Michal Abrahamowicz & Gabriel T Leonard & Michel Perron & Louis Richer & Suzanne Veillette & Daniel Gaudet & Tomáš Paus & Zdenka Pausova, 2013. "Clustering of the Metabolic Syndrome Components in Adolescence: Role of Visceral Fat," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0082368
    DOI: 10.1371/journal.pone.0082368
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082368
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082368&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0082368?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Evan D. Rosen & Bruce M. Spiegelman, 2006. "Adipocytes as regulators of energy balance and glucose homeostasis," Nature, Nature, vol. 444(7121), pages 847-853, December.
    2. Li, Baibing & Martin, Elaine B. & Morris, A. Julian, 2002. "On principal component analysis in L1," Computational Statistics & Data Analysis, Elsevier, vol. 40(3), pages 471-474, September.
    3. Andrew Woolston & Yu-Kang Tu & Paul D Baxter & Mark S Gilthorpe, 2012. "A Comparison of Different Approaches to Unravel the Latent Structure within Metabolic Syndrome," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-9, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Juan Carlos Chávez & Felipe J. Fonseca & Manuel Gómez-Zaldívar, 2017. "Resoluciones de disputas comerciales y desempeño económico regional en México. (Commercial Disputes Resolution and Regional Economic Performance in Mexico)," Ensayos Revista de Economia, Universidad Autonoma de Nuevo Leon, Facultad de Economia, vol. 0(1), pages 79-93, May.
    2. Chen, Ray-Bing & Chen, Ying & Härdle, Wolfgang K., 2014. "TVICA—Time varying independent component analysis and its application to financial data," Computational Statistics & Data Analysis, Elsevier, vol. 74(C), pages 95-109.
    3. Yan Yu Chen & Chun-Cheih Chao & Fu-Chen Liu & Po-Chen Hsu & Hsueh-Fen Chen & Shih-Chi Peng & Yung-Jen Chuang & Chung-Yu Lan & Wen-Ping Hsieh & David Shan Hill Wong, 2013. "Dynamic Transcript Profiling of Candida albicans Infection in Zebrafish: A Pathogen-Host Interaction Study," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-16, September.
    4. Plat, Richard, 2009. "Stochastic portfolio specific mortality and the quantification of mortality basis risk," Insurance: Mathematics and Economics, Elsevier, vol. 45(1), pages 123-132, August.
    5. Kondylis, Athanassios & Whittaker, Joe, 2008. "Spectral preconditioning of Krylov spaces: Combining PLS and PC regression," Computational Statistics & Data Analysis, Elsevier, vol. 52(5), pages 2588-2603, January.
    6. Simplice A. Asongu & Nicholas M. Odhiambo, 2019. "Governance, capital flight and industrialisation in Africa," Journal of Economic Structures, Springer;Pan-Pacific Association of Input-Output Studies (PAPAIOS), vol. 8(1), pages 1-22, December.
    7. M. J. Aziakpono & S. Kleimeier & H. Sander, 2012. "Banking market integration in the SADC countries: evidence from interest rate analyses," Applied Economics, Taylor & Francis Journals, vol. 44(29), pages 3857-3876, October.
    8. Bianca Maria Colosimo & Luca Pagani & Marco Grasso, 2024. "Modeling spatial point processes in video-imaging via Ripley’s K-function: an application to spatter analysis in additive manufacturing," Journal of Intelligent Manufacturing, Springer, vol. 35(1), pages 429-447, January.
    9. Ouyang, Yaofu & Li, Peng, 2018. "On the nexus of financial development, economic growth, and energy consumption in China: New perspective from a GMM panel VAR approach," Energy Economics, Elsevier, vol. 71(C), pages 238-252.
    10. Fan, Cheng & Sun, Yongjun & Zhao, Yang & Song, Mengjie & Wang, Jiayuan, 2019. "Deep learning-based feature engineering methods for improved building energy prediction," Applied Energy, Elsevier, vol. 240(C), pages 35-45.
    11. Ionela Munteanu & Adriana Grigorescu & Elena Condrea & Elena Pelinescu, 2020. "Convergent Insights for Sustainable Development and Ethical Cohesion: An Empirical Study on Corporate Governance in Romanian Public Entities," Sustainability, MDPI, vol. 12(7), pages 1-17, April.
    12. Daniel Boss & Annick Hoffmann & Benjamin Rappaz & Christian Depeursinge & Pierre J Magistretti & Dimitri Van de Ville & Pierre Marquet, 2012. "Spatially-Resolved Eigenmode Decomposition of Red Blood Cells Membrane Fluctuations Questions the Role of ATP in Flickering," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    13. Doukas, Haris & Papadopoulou, Alexandra & Savvakis, Nikolaos & Tsoutsos, Theocharis & Psarras, John, 2012. "Assessing energy sustainability of rural communities using Principal Component Analysis," Renewable and Sustainable Energy Reviews, Elsevier, vol. 16(4), pages 1949-1957.
    14. Paschalis Arvanitidis & Athina Economou & Christos Kollias, 2016. "Terrorism’s effects on social capital in European countries," Public Choice, Springer, vol. 169(3), pages 231-250, December.
    15. Rizvi, Syed Kumail Abbas & Rahat, Birjees & Naqvi, Bushra & Umar, Muhammad, 2024. "Revolutionizing finance: The synergy of fintech, digital adoption, and innovation," Technological Forecasting and Social Change, Elsevier, vol. 200(C).
    16. Teerachai Amnuaylojaroen & Pavinee Chanvichit, 2024. "Historical Analysis of the Effects of Drought on Rice and Maize Yields in Southeast Asia," Resources, MDPI, vol. 13(3), pages 1-18, March.
    17. -, 2015. "The effects of climate change on the coasts of Latin America and the Caribbean: Climate variability, dynamics and trends," Documentos de Proyectos 39866, Naciones Unidas Comisión Económica para América Latina y el Caribe (CEPAL).
    18. Dorota Toczydlowska & Gareth W. Peters & Man Chung Fung & Pavel V. Shevchenko, 2017. "Stochastic Period and Cohort Effect State-Space Mortality Models Incorporating Demographic Factors via Probabilistic Robust Principal Components," Risks, MDPI, vol. 5(3), pages 1-77, July.
    19. Weili Duan & Bin He & Daniel Nover & Guishan Yang & Wen Chen & Huifang Meng & Shan Zou & Chuanming Liu, 2016. "Water Quality Assessment and Pollution Source Identification of the Eastern Poyang Lake Basin Using Multivariate Statistical Methods," Sustainability, MDPI, vol. 8(2), pages 1-15, January.
    20. Joanna Jasnos, 2021. "Hydrogeochemical Characteristics of Geothermal Waters from Mesozoic Formations in the Basement of the Central Part of the Carpathian Foredeep and the Carpathians (Poland) Using Multivariate Statistica," Energies, MDPI, vol. 14(13), pages 1-31, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0082368. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.