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Intrinsic dynamics of an enzyme underlies catalysis

Author

Listed:
  • Elan Z. Eisenmesser

    (Brandeis University)

  • Oscar Millet

    (University of Toronto
    Parc Cientific de Barcelona)

  • Wladimir Labeikovsky

    (Brandeis University)

  • Dmitry M. Korzhnev

    (University of Toronto)

  • Magnus Wolf-Watz

    (Brandeis University
    University of Umeå)

  • Daryl A. Bosco

    (Brandeis University
    The Scripps Research Institute, Department of Chemistry)

  • Jack J. Skalicky

    (National High Magnetic Field Laboratory at Florida State University
    University of Utah School of Medicine)

  • Lewis E. Kay

    (University of Toronto)

  • Dorothee Kern

    (Brandeis University)

Abstract

Split personality Here's a new way to look at familiar enzymes. A new technology that can detect ultra-rare states of a protein (cyclophilin A in this instance) shows that rather than having a range of conformations to which it resorts during catalysis, it has them all before it starts. Protein motions needed for catalysis are intrinsic to the enzyme and take in the whole molecule, not just the traditional centre of attention, the active site.

Suggested Citation

  • Elan Z. Eisenmesser & Oscar Millet & Wladimir Labeikovsky & Dmitry M. Korzhnev & Magnus Wolf-Watz & Daryl A. Bosco & Jack J. Skalicky & Lewis E. Kay & Dorothee Kern, 2005. "Intrinsic dynamics of an enzyme underlies catalysis," Nature, Nature, vol. 438(7064), pages 117-121, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7064:d:10.1038_nature04105
    DOI: 10.1038/nature04105
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    Citations

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    Cited by:

    1. Dong Long & Rafael Brüschweiler, 2011. "In Silico Elucidation of the Recognition Dynamics of Ubiquitin," PLOS Computational Biology, Public Library of Science, vol. 7(4), pages 1-9, April.
    2. Santiago Esteban-Martín & Robert Bryn Fenwick & Jörgen Ådén & Benjamin Cossins & Carlos W Bertoncini & Victor Guallar & Magnus Wolf-Watz & Xavier Salvatella, 2014. "Correlated Inter-Domain Motions in Adenylate Kinase," PLOS Computational Biology, Public Library of Science, vol. 10(7), pages 1-7, July.
    3. Gregory D Friedland & Nils-Alexander Lakomek & Christian Griesinger & Jens Meiler & Tanja Kortemme, 2009. "A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family," PLOS Computational Biology, Public Library of Science, vol. 5(5), pages 1-16, May.
    4. Maciej Majewski & Adrià Pérez & Philipp Thölke & Stefan Doerr & Nicholas E. Charron & Toni Giorgino & Brooke E. Husic & Cecilia Clementi & Frank Noé & Gianni Fabritiis, 2023. "Machine learning coarse-grained potentials of protein thermodynamics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Timothy R Lezon & Ivet Bahar, 2010. "Using Entropy Maximization to Understand the Determinants of Structural Dynamics beyond Native Contact Topology," PLOS Computational Biology, Public Library of Science, vol. 6(6), pages 1-12, June.
    6. Diego F. Gauto & Pavel Macek & Duccio Malinverni & Hugo Fraga & Matteo Paloni & Iva Sučec & Audrey Hessel & Juan Pablo Bustamante & Alessandro Barducci & Paul Schanda, 2022. "Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Giacomo Janson & Gilberto Valdes-Garcia & Lim Heo & Michael Feig, 2023. "Direct generation of protein conformational ensembles via machine learning," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Fabian Paul & Thomas R Weikl, 2016. "How to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation Rates," PLOS Computational Biology, Public Library of Science, vol. 12(9), pages 1-17, September.
    9. Torgeir R Hvidsten & Astrid Lægreid & Andriy Kryshtafovych & Gunnar Andersson & Krzysztof Fidelis & Jan Komorowski, 2009. "A Comprehensive Analysis of the Structure-Function Relationship in Proteins Based on Local Structure Similarity," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-9, July.

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