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Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells

Author

Listed:
  • Kenneth D. Harris

    (The State University of New Jersey)

  • Darrell A. Henze

    (The State University of New Jersey)

  • Hajime Hirase

    (The State University of New Jersey)

  • Xavier Leinekugel

    (The State University of New Jersey)

  • George Dragoi

    (The State University of New Jersey)

  • Andras Czurkó

    (The State University of New Jersey)

  • György Buzsáki

    (The State University of New Jersey)

Abstract

According to the temporal coding hypothesis1, neurons encode information by the exact timing of spikes. An example of temporal coding is the hippocampal phase precession phenomenon, in which the timing of pyramidal cell spikes relative to the theta rhythm shows a unidirectional forward precession during spatial behaviour2,3. Here we show that phase precession occurs in both spatial and non-spatial behaviours. We found that spike phase correlated with instantaneous discharge rate, and precessed unidirectionally at high rates, regardless of behaviour. The spatial phase precession phenomenon is therefore a manifestation of a more fundamental principle governing the timing of pyramidal cell discharge. We suggest that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes4,5.

Suggested Citation

  • Kenneth D. Harris & Darrell A. Henze & Hajime Hirase & Xavier Leinekugel & George Dragoi & Andras Czurkó & György Buzsáki, 2002. "Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells," Nature, Nature, vol. 417(6890), pages 738-741, June.
  • Handle: RePEc:nat:nature:v:417:y:2002:i:6890:d:10.1038_nature00808
    DOI: 10.1038/nature00808
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    Cited by:

    1. Zhenrui Liao & Kevin C. Gonzalez & Deborah M. Li & Catalina M. Yang & Donald Holder & Natalie E. McClain & Guofeng Zhang & Stephen W. Evans & Mariya Chavarha & Jane Simko & Christopher D. Makinson & M, 2024. "Functional architecture of intracellular oscillations in hippocampal dendrites," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Eleonora Russo & Nadine Becker & Aleks P. F. Domanski & Timothy Howe & Kipp Freud & Daniel Durstewitz & Matthew W. Jones, 2024. "Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Miles Wischnewski & Harry Tran & Zhihe Zhao & Sina Shirinpour & Zachary J. Haigh & Jonna Rotteveel & Nipun D. Perera & Ivan Alekseichuk & Jan Zimmermann & Alexander Opitz, 2024. "Induced neural phase precession through exogenous electric fields," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Mamiko Arai & Vicky Brandt & Yuri Dabaghian, 2014. "The Effects of Theta Precession on Spatial Learning and Simplicial Complex Dynamics in a Topological Model of the Hippocampal Spatial Map," PLOS Computational Biology, Public Library of Science, vol. 10(6), pages 1-14, June.

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